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Table 2 Multivariate Cox regression for 28-day mortality (propensity-matched population: n = 186)

From: Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis

 HR95% CIp
Net fluid balance1.001.00–1.00< 0.001
Steroids use*4.661.94–11.180.001
Hyperlactatemia**3.611.41–9.220.007
VE-VPs0.310.17–0.57< 0.001
  1. SOFA Sequential Organ Failure Assessment, VE-VPs very early start of vasopressor support
  2. *Low-dose steroids (200–300 mg/day) used in the context of shock
  3. **Lactate levels > 2.0 mmol/L (Third International Consensus Definitions for Sepsis and Septic Shock—Sepsis 3.0—considers the presence of suspected infection accompanying life-threatening organ dysfunction, use of vasopressors, MAP < 65 mmHg, and lactate levels > 2 mmol/L as septic shock)