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Fig. 9 | Critical Care

Fig. 9

From: Cathelicidin preserves intestinal barrier function in polymicrobial sepsis

Fig. 9

Pretreatment with VD3 up-regulated the ileal expression of cathelicidin in sepsis. Effect of VD3 on expression of mCRAMP in distal ileum of wild-type mice at 24 h after CLP were determined by immunofluorescence and (a) real-time quantitative PCR (b). n = 6 per group, error bars denote standard error of the mean. c, d Prophylactic efficacy of VD3 required cathelicidin in CLP-induced polymicrobial sepsis. Cathelicidin-knockout mice (Cnlp−/−) pretreated with water or VD3 by oral gavage at 48 h, 24 h, and 1 h before CLP (n = 5 per group). There was no significant difference between water control and VD3 group in terms of c 7-day mortality as well as d MSS score in Cnlp−/− mice. **P < 0.01; ****P < 0.0001

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