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Fig. 8 | Critical Care

Fig. 8

From: Cathelicidin preserves intestinal barrier function in polymicrobial sepsis

Fig. 8

Effect of VD3 on peritonitis-induced polymicrobial sepsis. a All mice (n = 6 per group) underwent CLP surgery pretreated with water or VD3 by gavage at 48 h, 24 h, and 1 h before CLP. Mice pretreated with VD3 had b decreased 7-day mortality (n = 10 per group) and c significantly lower MSS score (n = 10 per group) and d lower level of fluorescein dextran entering the bloodstream (n = 6 per group). Mucin production increased in mice pretreated with VD3. The expression levels of e Muc1 and f Muc2 were detected in mice pretreated with VD3 compared to mice pretreated with water after CLP-induced sepsis by immunoblotting. Error bars denote standard error of the mean. **P < 0.01; ***P < 0.001; ****P < 0.0001

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