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Fig. 5 | Critical Care

Fig. 5

From: Cathelicidin preserves intestinal barrier function in polymicrobial sepsis

Fig. 5

Ileal transcriptomes of septic cathelicidin wild-type and knockout mice. a Heatmap was generated using genes in cluster 8 and cluster 16. The transcriptome datasets from the septic and non-septic wild-type mice but not the cathelicidin knockout mice were published in Inflamm Res. 2019; 68 [9]:723–726. b Protein-protein interaction network was constructed in STRING using the source of “experiments,” “databases,” and “co-expression” and visualized by cytoscape. Nodes in round shape have a degree large than 22. Several inflammation-related genes were highlighted as hub genes according to the topology analysis. c, d Top 30 KEGG and Reactome pathways were plotted. A series of inflammation related pathways were enriched by both sources

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