Fig. 1
From: Cathelicidin preserves intestinal barrier function in polymicrobial sepsis
Murine cathelicidin-related antimicrobial peptide (mCRAMP) is upregulated after cecal-ligation and puncture (CLP) induced sepsis in wild-type (WT) mice (n = 6 per group) from which total RNA and protein were collected from distal ileum over a period of time for a real-time PCR and b immunofluorescence for mCRAMP. Genetic knockout (KO) of Cnlp led to f reduced survival and e higher sepsis severity score (n = 18 for WT mice; n = 17 for KO mice). FITC dextran 4 kD was orally gavaged at 21 h after CLP with serum harvested after 3 h. Genetic KO of Cnlp led to c increased serum concentration of FITC-labeled dextran 4 kD (FD-4) and d increased bacterial DNA upon experimental sepsis. Error bars denote standard error of the mean. *P < 0.05; ***P < 0.001; ****P < 0.0001