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Table 5 Comparison between volunteers and ICU patients with normal and elevated plasma lactate

From: Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

 Volunteers (n = 6)ICU, normal lactate (n = 6)ICU, elevated lactate (n = 4)
P-lactate [mmol/L]0.7 (0.4–0.9)0.8 (0.6–1.5)3.8 (2.1–4.9)
Ra [μmol/kg/min]11.5 (8.5–18.5)14.5 (12.3–18.4)33.2 (27.3–44.2)
Metabolic clearance [L/min]1.43 (1.22–2.27)1.30 (0.77–1.77)0.80 (0.57–1.17)
Vc [L]9.0 (7.0–14.2)8.4 (5.3–13.5)10.3 (7.6–14.7)
  1. Normal lactate ≤ 2 mmol/L, elevated lactate > 2 mmol/L. Data are presented as median (range). Ra rate of appearance of lactate, Vc central distribution volume