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Table 6 Effect of diuretic use on urine output test characteristics to predict successful discontinuation of RRT

From: Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)

Study

Cutoff Value

# Patients

Sensitivity (95% CI)

Specificity (95% CI)

AUROC (95% CI)

Jeon et al., diuretics [37]

191 mL/day

557

81.2 (77.6, 84.5)

71.6 (68.0, 75.0)

0.821 (0.797, 0.845)

Jeon et al., diuretics (oliguric) [37]

125 mL/day

619

72.1 (64.6, 78.8)

68.8 (61.3, 75.7)

0.745 (0.692, 0.798)

Raurich et al., no diuretics [27]

178 mL/6 h

42

–

–

0.73 (0.58, 0.89) before, 0.85(0.72, 0.99) after cessation

Raurich et al., diuretics [27]

178 mL/6 h

59

–

–

0.86 (0.76, 0.88) before, 0.94 (0.88, 1.0) after cessation

Uchino et al., no diuretics [21]

436 mL/day

335

46.5

80.9

0.845 (0.799, 0.883)

Uchino et al., diuretics [21]

2330 mL/day

194

–

–

0.671 (0.585, 0.750)

Yoshida et al., no diuretics [17]

1810 mL/day

22

61.5

77.8

0.71 (0.46, 0.88)

Yoshida et al., diuretics [17]

1720 mL/day

30

72.0

100.0

0.84 (0.64, 0.94)