Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)

Table 3 Kidney biomarkers used to predict successful discontinuation of RRT

Test/parameter	Value/cut-off	Timing	RRT modality	Sn	Sp	OR	AUROC	Publication
Serum cystatin C
	2.47 mg/L	Initiation	CRRT	0.95	0.54		0.75	Yang et al. [30]
	2.98 mg/L	ICU admission	CRRT	0.81	0.84	4.76	0.87	Zhang et al. [31]
	2.97 mg/L	Discontinuation	CRRT	0.80	0.58		0.71	Yang et al. [30]
	1.85 mg/L	Discontinuation	CRRT	0.76	0.63	0.29	0.74	Kim et al. [28]
	Not specified	Discontinuation	CRRT				0.74	Yang et al. [29]
Cystatin C-based eGFR
	32.9 mL/min/1.73m²	Discontinuation	CRRT	0.65	0.76	1.25	0.75	Kim et al. [40]
NT-proBNP
	> 15,767	Initiation	CRRT			0.54	0.58	Han et al. [18]
NGAL
	Not specified	Discontinuation	CRRT	0.91	0.45		0.65	Kim et al. [28]
	403 ng/mL	Discontinuation	CRRT	0.91	0.61		0.81	Chen et al. [19]
	Not specified	Discontinuation	CRRT				0.66	Yang et al. [30]
IL-18
	Not specified	Discontinuation	CRRT				0.60	Yang et al. [30]
IL-6
	Not specified	Discontinuation	CRRT				0.55	Yang et al. [30]
Serum osteopontin
	Not specified	Discontinuation	CRRT				0.61	Yang et al. [30]

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