Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)

Table 2 Conventional biochemical criteria used to predict successful discontinuation of RRT

Test/parameter	Value/cut-off	Timing	RRT modality	Sn	Sp	OR	AUROC	Publication
Serum creatinine
	299.68 umol/L	Initiation	CRRT	0.79	0.79		0.75	Yoshida et al. [17]
	Not specified	Initiation	CRRT				0.59	Han et al. [18]
	224 umol/L	Discontinuation	CRRT	0.72	0.77		0.76	Chen et al. [19]
	Per umol/L increase	Discontinuation	CRRT				0.48	Frohlich et al. [20]
	Not specified	Discontinuation	CRRT				0.64	Uchino et al. [21]
	Not specified	Discontinuation	CRRT				0.73	Katayama et al. [22]
2-h creatinine clearance
	23 mL/min	12 h pre-stop	Not specified			1.11	0.82	Frohlich et al. [20]
Residual creatinine clearance
	Not specified	24–48 h pre-stop	Not specified				0.90	Gleeson et al. [23]
Kinetic eGFR
	20.58 mL/min/1.73 m²	Discontinuation	CRRT	0.71	0.92		0.87	Yoshida et al. [17]
eGFR
	26.21 mL/min/1.73 m²	D1 post-stop	CRRT	0.71	0.85		0.83	Yoshida et al. [17]
24 h urine creatinine
	> 5.2 mol/24 h	D0 post-stop	CRRT, SLED,	0.57	0.96		0.76	Viallet et al. [26]
		D1	IHD	0.75	0.88		0.86
		D2		0.86	0.81		0.86
Urine urea
	> 148 mmol/L	Discontinuation	IHD, CRRT	0.65	0.90		0.82	Aniort et al. [25]
Daily urinary urea excretion
	> 1.35 mmol/kg/day	Discontinuation	IHD, CRRT	0.89	0.97		0.96	Aniort et al. [25]

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