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Table 1 Studies retrieved and parameters identified in a systematic review

From: Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)

StudyStudy typePopulation#Patients with discontinuation of RRTQuality (NOS)Parameters identifiedDefinition of weaning success
Chen et al. [19]Prospective cohortAdult patients receiving CRRT789Urine output, plasma NGAL, serum Cr at discontinuationSurvival with no requirement for RRT within 7 days
Yoshida et al. [17]Retrospective cohortGeneral ICU patients requiring RRT388Serum Cr, urine output, eGFR, kinetic eGFR at discontinuationSurvival off CRRT ×  48 h, off IHD for 7 days
Jeon et al. [37]Retrospective cohortAdult patients with AKI on CRRT5179Urine output, multivariate model at discontinuationSurvival with no re-initiation of RRT within 3 days
Itenov et al. [38]Prospective cohortAdult patients with AKI7198Multivariate modelSurvival with no re-initiation of RRT for 5 days
Kim et al. [28]Prospective cohortICU patients weaned from CRRT898Serum cystatin C, plasma NGAL, urine outputSurvival with no re-initiation of RRT for 14 days
Raurich et al. [27]Retrospective cohortICU patients requiring CRRT who underwent weaning tests679Urine output with/without diuretics, multivariate modelUrine output recovered, RRT not required
Romero-Gonzalez et al. [39]Retrospective cohortPatients with AKI treated with CRRT37Urine outputIndependence from RRT 14 days after discontinuation
Yang et al. [29]Retrospective cohortICU patients weaned from CRRT, PIRRT, IHD3027Serum cystatin CSurvival with no requirement for RRT 30 days after discharge
Yang et al. [30]Prospective observational studyICU patients who weaned from CRRT1027Serum cystatin CSurvival at 60 days with Cr no more than 1.5X baseline
Aniort et al. [25]Retrospective cohortICU patients receiving IHD for at least 7 days678Daily urine urea, eUrea, urine outputNo requirement for further dialysis sessions during ICU stay
Katayama et al. [22]Retrospective cohortGeneral ICU patients receiving CRRT1168Urine output, CrSurvival with no re-initiation of CRRT for 7 days
Han et al. [18]Retrospective cohortGeneral ICU patients requiring CRRT1607Multivariate model, CrComplete or partial recovery of AKI within 2 weeks
Kim et al. [40]Prospective cohortGeneral ICU patients requiring RRT894Cystatin C-based eGFRSurvival with no re-initiation of RRT for 14 days
Viallet et al. [26]Retrospective cohortAdult patients who received CRRT, IHD or SLED and survived ICU stay267Urine output, urine CrCessation of RRT for at least 15 days
Gleeson et al. [23]Retrospective cohortGeneral ICU patients requiring RRT676Residual creatinine clearanceNot specified
Ohnuma et al. [41]Retrospective cohortGeneral ICU patients requiring CRRT or IHD1095Urine outputFree from RRT for 7 days after discontinuation
Frohlich et al. [20]Retrospective cohortGeneral ICU patients requiring CRRT5362 h CrCl, Cr, urine output at discontinuationFree from RRT for 7 days after discontinuation
Heise [42]Retrospective cohortSurgical ICU patients requiring CRRT2229Multivariate modelDischarged from ICU with no further RRT during hospital stay
Zhang et al. [31]Retrospective cohortGeneral ICU patients requiring CRRT1458Serum cystatin CSurvivors who were not dependent on RRT
Solymos [43]Retrospective cohortGeneral ICU patients requiring CRRT2362 h CrClFree from RRT for 5 days after discontinuation
Franzen et al. [44]Retrospective cohortMedical ICU patients requiring IHD207IHD ultrafiltrationNo need for long-term RRT
Uchino et al. [21]Prospective cohortGeneral ICU patients requiring CRRT3137Urine output, CrFree from RRT for 7 days after discontinuation
Wu et al. [45]Case controlSurgical ICU patients requiring CRRT or IHD647Multivariate modelFree from RRT for 30 days after discontinuation