Table 1 Baseline patient and healthy subject characteristics

 Age (years)

26.7 ± 4.6

66.6 ± 20.9

 Gender (male)

17 (54.8)

7 (58)

 Body mass index (kg/m²)

22.6 [19.9–26.3]

25.2 [15.5–32.8]

 SAPS II

–

59.1 ± 25.4

 SOFA at admission

–

8.1 ± 6.2

Primary reason for admission

–

 Respiratory distress

7 (57)

 Coma

2 (17)

 Sepsis

2 (17)

 Acute kidney injury

1 (8)

Clinical management during the first week in ICU

–

 Use of continuous neuromuscular blockade infusion

5 (42)

 Use of systemic steroids

5 (42)

 Duration of sedation (days)

4 [2–7]

 Duration of invasive mechanical ventilation (days)

5.8 [3.7–7]

 Duration of controlled mechanical ventilation (days)

1.7 [0.9–7]

 Cumulative fluid balance at day 3 (ml)

6740 ± 2828