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Table 3 Comparison of 30-day mortality and exploratory endpoint according to treatment regimens

From: Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae

 

Antibiotic regimens

N (%)

HR (95%CI)

p value

30-day mortality

 

COL containing-regimen

27/61 (44.3%)

Ref variable

Ref variable

CAZ-AVI containing-regimen

3/13 (23.1%)

0.424 (0.129–1.391)

0.157

Other regimens

7/17 (41.2%)

0.799 (0.366–1.746)

0.574

Composite endpoint

 30-day mortality OR nephrotoxicity

COL containing-regimen

42/61 (68.9%)

Ref variable

Ref variable

CAZ-AVI containing-regimen

3/13 (23.1%)

0.231 (0.071–0.745)

0.014

Other regimens

8/17 (47.1%)

0.503 (0.245–1.034)

0.061

  1. COL colistin, CAZ-AVI ceftazidime-avibactam, Ref reference. Statistical significant p value are indicated in italics