Outcome | Naloxone (n = 27) | Buprenorphine 10 μg/kg (n = 27) | Buprenorphine 15 μg/kg (n = 27) |
---|---|---|---|
Response to bolus antidote doses | Complete 13 (48%) Partial 13 (48%) No response 1 (4%) | Complete 23 (85%) Relative 3 (11%) No response 1 (4%) | Complete 27 (100%) Partial 0 No response 0 |
Opioid withdrawal | 15 (56%) | 0 | 6 (22%) |
Further apnea | 6 (22%) | 4 (15%) | 3 (11%) |
Aspiration | 1 (4%) | 5 (18%) | 1 (4%) |
Intubation | 8 (30%) | 4 (15%) | 1 (4%) |
Continuing sedation | 9 (33%) | 0 | 3 (11%) |