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Table 3 Per-protocol comparison of outcomes in three arms of the study (n = 81)

From: Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial

OutcomeNaloxone (n = 27)Buprenorphine 10 μg/kg (n = 27)Buprenorphine 15 μg/kg (n = 27)
Response to bolus antidote dosesComplete 13 (48%)
Partial 13 (48%)
No response 1 (4%)
Complete 23 (85%)
Relative 3 (11%)
No response 1 (4%)
Complete 27 (100%)
Partial 0
No response 0
Opioid withdrawal15 (56%)06 (22%)
Further apnea6 (22%)4 (15%)3 (11%)
Aspiration1 (4%)5 (18%)1 (4%)
Intubation8 (30%)4 (15%)1 (4%)
Continuing sedation9 (33%)03 (11%)