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Table 1 Demographic and baseline clinical variables in the three treatment arms

From: Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial

Variable †Naloxone (n = 27)Buprenorphine 10 μg/kg (n = 27)Buprenorphine 15 μg/kg (n = 27)
Mean [IQR] Age (years) (min, max)40 [24 to 50] (18, 66)44 [27 to 53] (15, 63)48 [36 to 62] (23, 77)
Mean [IQR] Methadone dose (mg)* (min, max)100 [50 to 200](20, 350)150 [79 to 325] (40, 1400)100 [40 to 175] (25, 800)
Formulation: syrup18 (67%)19 (70%)23 (85%)
Tablet5 (19%)6 (22%)3 (11%)
Unknown4 (15%)2 (8%)1 (4%)
Mean [IQR] Glasgow coma score (min, max)14 [12 to 15] (6, 15)15 [13 to 15] (10, 15)13 [11 to 15] (8, 15)
Mean [IQR] Respiratory rate (min, max)12 [8 to 16] (6, 30)15 [14 to 18] (6, 25)15 [10 to 16] (7, 22)
Mean [IQR] Initial naloxone dose (min, max)(n = 16, 19, 18)1.0 [0.8 to 2.3] (0.4, 4.8)0.8 [0.8 to 1.2] (0.4, 2.4)1 [0.7 to 2] (0.4, 2)
Mean [IQR] Time to admission (h)* (min, max)9 [5 to 12] (2, 24)12 [7 to 20] (2, 72)5 [5 to 12] (2, 24)
Mean [IQR] Initial pH (min, max)7.3 [7.2 to 7.3] (7.1, 7.5)7.3 [7.2 to 7.3] (7.1, 7.4)7.3 [7.2 to 7.3] (7.1, 7.4)
Mean [IQR] Initial pCO2 (mmHg) (min, max)56 [46 to 62] (16, 75)57 [51 to 65] (45, 79)62 [52 to 68] (20, 88)
  1. † All values: Median [IQR] (min, max) unless otherwise specified. *Missing data in 27 cases