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Table 3 Multivariate analyses of survival in placebo treatment arm

From: Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

Characteristic

Hazard ratio (95% CI)

P value

Full model

 Baseline ANG I/II ratio

0.52 (0.30–0.89)

0.0180

 Age ≥65 years

1.18 (0.73–1.90)

0.4925

 Gender, male

1.04 (0.62–1.75)

0.8710

 Baseline albumin <2.5 g/dL

1.38 (0.83–2.28)

0.2179

 Baseline MAP <65 mmHg

1.87 (1.14–3.07)

0.0125

 Baseline APACHE II score >30

1.63 (0.98–2.71)

0.0620

 Exposure to ACEI, yes

0.34 (0.11–1.03)

0.0554

 Baseline NE equivalent dose ≥0.5 μg/kg/min

1.59 (0.95–2.65)

0.0772

 Medical history of ARDS, yes

1.16 (0.62–2.16)

0.6485

 Baseline ANG I <253 pg/mL

0.54 (0.27–1.12)

0.0968

 Baseline ANG II <83.75 pg/mL

1.47 (0.70–3.09)

0.3049

  1. ACEI angiotensin-converting enzyme inhibitor, APACHE II Acute Physiology and Chronic Health Evaluation II, ANG angiotensin, ARDS acute respiratory distress syndrome, CI confidence interval, MAP mean arterial pressure, NE norepinephrine
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