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Table 3 Multivariate analyses of survival in placebo treatment arm

From: Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

CharacteristicHazard ratio (95% CI)P value
Full model
 Baseline ANG I/II ratio0.52 (0.30–0.89)0.0180
 Age ≥65 years1.18 (0.73–1.90)0.4925
 Gender, male1.04 (0.62–1.75)0.8710
 Baseline albumin <2.5 g/dL1.38 (0.83–2.28)0.2179
 Baseline MAP <65 mmHg1.87 (1.14–3.07)0.0125
 Baseline APACHE II score >301.63 (0.98–2.71)0.0620
 Exposure to ACEI, yes0.34 (0.11–1.03)0.0554
 Baseline NE equivalent dose ≥0.5 μg/kg/min1.59 (0.95–2.65)0.0772
 Medical history of ARDS, yes1.16 (0.62–2.16)0.6485
 Baseline ANG I <253 pg/mL0.54 (0.27–1.12)0.0968
 Baseline ANG II <83.75 pg/mL1.47 (0.70–3.09)0.3049
  1. ACEI angiotensin-converting enzyme inhibitor, APACHE II Acute Physiology and Chronic Health Evaluation II, ANG angiotensin, ARDS acute respiratory distress syndrome, CI confidence interval, MAP mean arterial pressure, NE norepinephrine