Table 2 Resuscitation therapies during the 8-h intervention period
Fluid responders | Non-fluid responders | p value | |
|---|---|---|---|
Fluids administered pre-protocol (mL) | 2000 [1194–2643] | 2000 [1200–2500] | 0.86 |
FR assessments performed (N) | 8 [7–10] | 5 [5–6] | 0.03 |
Fluid bolus 0–2 h (mL) | 1000 [500–1500] | 0 [0–0] | 0.0001 |
Fluid bolus 0–8 h (mL) | 1500 [1000–2500] | 0 [0–500] | 0.0001 |
Total fluids 0–8 h (mL) | 2500 [1594–3840] | 1748 [1090–2881] | 0.003 |
Fluid balance 8 h (mL) | 1672 [894–2842] | 1244 [395–2251] | 0.006 |
Norepinephrine dose 0 h (mcg/kg/min) | 0.22 [0.1–0.4] | 0.21 [0.12–0.4] | 0.8 |
Norepinephrine dose 2 h (mcg/kg/min) | 0.22 [0.09–0.45] | 0.23 [0.11–0.4] | 0.5 |
Norepinephrine dose 4 h (mcg/kg/min) | 0.24 [0.1–0.42] | 0.20 [0.1–0.45] | 0.9 |
Norepinephrine dose 8 h (mcg/kg/min) | 0.24 [0.1–0.45] | 0.16 [0.08–0.4] | 0.3 |
Vasopressor test (%) | 74/242 (30.5%) | 46/106 (43.3%) | 0.02 |
Inodilator test (%) | 33/242 (13.6%) | 23/106 (21.6%) | 0.08 |