Skip to main content

Table 2 Resuscitation therapies during the 8-h intervention period

From: Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

  Fluid responders Non-fluid responders p value
Fluids administered pre-protocol (mL) 2000 [1194–2643] 2000 [1200–2500] 0.86
FR assessments performed (N) 8 [7–10] 5 [5–6] 0.03
Fluid bolus 0–2 h (mL) 1000 [500–1500] 0 [0–0] 0.0001
Fluid bolus 0–8 h (mL) 1500 [1000–2500] 0 [0–500] 0.0001
Total fluids 0–8 h (mL) 2500 [1594–3840] 1748 [1090–2881] 0.003
Fluid balance 8 h (mL) 1672 [894–2842] 1244 [395–2251] 0.006
Norepinephrine dose 0 h (mcg/kg/min) 0.22 [0.1–0.4] 0.21 [0.12–0.4] 0.8
Norepinephrine dose 2 h (mcg/kg/min) 0.22 [0.09–0.45] 0.23 [0.11–0.4] 0.5
Norepinephrine dose 4 h (mcg/kg/min) 0.24 [0.1–0.42] 0.20 [0.1–0.45] 0.9
Norepinephrine dose 8 h (mcg/kg/min) 0.24 [0.1–0.45] 0.16 [0.08–0.4] 0.3
Vasopressor test (%) 74/242 (30.5%) 46/106 (43.3%) 0.02
Inodilator test (%) 33/242 (13.6%) 23/106 (21.6%) 0.08
  1. Tests: Mann Whitney or Fisher’s exact test, accordingly
  2. FR fluid responsiveness