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Table 2 Resuscitation therapies during the 8-h intervention period

From: Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

 Fluid respondersNon-fluid respondersp value
Fluids administered pre-protocol (mL)2000 [1194–2643]2000 [1200–2500]0.86
FR assessments performed (N)8 [7–10]5 [5–6]0.03
Fluid bolus 0–2 h (mL)1000 [500–1500]0 [0–0]0.0001
Fluid bolus 0–8 h (mL)1500 [1000–2500]0 [0–500]0.0001
Total fluids 0–8 h (mL)2500 [1594–3840]1748 [1090–2881]0.003
Fluid balance 8 h (mL)1672 [894–2842]1244 [395–2251]0.006
Norepinephrine dose 0 h (mcg/kg/min)0.22 [0.1–0.4]0.21 [0.12–0.4]0.8
Norepinephrine dose 2 h (mcg/kg/min)0.22 [0.09–0.45]0.23 [0.11–0.4]0.5
Norepinephrine dose 4 h (mcg/kg/min)0.24 [0.1–0.42]0.20 [0.1–0.45]0.9
Norepinephrine dose 8 h (mcg/kg/min)0.24 [0.1–0.45]0.16 [0.08–0.4]0.3
Vasopressor test (%)74/242 (30.5%)46/106 (43.3%)0.02
Inodilator test (%)33/242 (13.6%)23/106 (21.6%)0.08
  1. Tests: Mann Whitney or Fisher’s exact test, accordingly
  2. FR fluid responsiveness