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Table 1 Baseline characteristics of study participants

From: Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

 

Fluid responders

Non-fluid responders

p value

N

242

106

 

Age (years)

63 [50–74]

66 [53–75]

0.56

Sex, N (%)

Female, 115 (48%)

Female, 51 (48%)

0.86

Study arm, N (%)

LTR, 115 (48%)

LTR, 57 (54%)

0.3

PPTR, 127 (52%)

PPTR, 49 (46%)

 

APACHE score

23 [18–29]

21 [15–27]

0.09

SOFA score

10 [7–12]

9 [7–12]

0.52

Charlson index

3 [1–5]

3 [1–5]

0.4

Sepsis origin, N (%)

Abdominal, 92 (38%)

Abdominal, 34 (32%)

0.3

Pulmonary, 71 (29%)

Pulmonary, 25 (24%)

 

Urinary, 53 (22%)

Urinary, 24 (23%)

 

Other, 26 (11%)

Other, 23 (21%)

 

MAP (mmHg)

66 [60–75]

67 [62–78]

0.2

Pulse pressure (mmHg)

45 [35–59]

46 [33–59]

0.76

DBP (mmhg)

51 [45–59]

52 [44–59]

0.5

CVP (mmHg)

9 [5–12]

10 [7–14]

0.001

Pre-protocol fluids (mL/kg)

26.7 [17–40]

26.8 [20–38]

0.8

Norepinephrine dose (mcg/kg/min)

0.22 [0.1–0.4]

0.21 [0.12–0.4]

0.8

Arterial lactate (mmol/L)

3.8 [2.8–5.5]

3.6 [2.8–5.5]

0.4

CRT (s)

5 [4–6]

4 [3–6]

0.002

ScvO2 (%)

72 [63–78]

74 [65–81]

0.27

Delta pCO2(v-a)

7 [5–10]

7 [5–10]

0.57

  1. Tests: Mann-Whitney or Fisher’s exact test, accordingly
  2. LTR lactate level-targeted group, PPTR peripheral perfusion-targeted group, APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA sequential organ failure assessment score, MAP mean arterial pressure, DBP diastolic blood pressure, CVP central venous pressure, CRT capillary refill time, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure