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Table 1 Baseline characteristics of study participants

From: Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

  Fluid responders Non-fluid responders p value
N 242 106  
Age (years) 63 [50–74] 66 [53–75] 0.56
Sex, N (%) Female, 115 (48%) Female, 51 (48%) 0.86
Study arm, N (%) LTR, 115 (48%) LTR, 57 (54%) 0.3
PPTR, 127 (52%) PPTR, 49 (46%)  
APACHE score 23 [18–29] 21 [15–27] 0.09
SOFA score 10 [7–12] 9 [7–12] 0.52
Charlson index 3 [1–5] 3 [1–5] 0.4
Sepsis origin, N (%) Abdominal, 92 (38%) Abdominal, 34 (32%) 0.3
Pulmonary, 71 (29%) Pulmonary, 25 (24%)  
Urinary, 53 (22%) Urinary, 24 (23%)  
Other, 26 (11%) Other, 23 (21%)  
MAP (mmHg) 66 [60–75] 67 [62–78] 0.2
Pulse pressure (mmHg) 45 [35–59] 46 [33–59] 0.76
DBP (mmhg) 51 [45–59] 52 [44–59] 0.5
CVP (mmHg) 9 [5–12] 10 [7–14] 0.001
Pre-protocol fluids (mL/kg) 26.7 [17–40] 26.8 [20–38] 0.8
Norepinephrine dose (mcg/kg/min) 0.22 [0.1–0.4] 0.21 [0.12–0.4] 0.8
Arterial lactate (mmol/L) 3.8 [2.8–5.5] 3.6 [2.8–5.5] 0.4
CRT (s) 5 [4–6] 4 [3–6] 0.002
ScvO2 (%) 72 [63–78] 74 [65–81] 0.27
Delta pCO2(v-a) 7 [5–10] 7 [5–10] 0.57
  1. Tests: Mann-Whitney or Fisher’s exact test, accordingly
  2. LTR lactate level-targeted group, PPTR peripheral perfusion-targeted group, APACHE II Acute Physiology And Chronic Health Evaluation II, SOFA sequential organ failure assessment score, MAP mean arterial pressure, DBP diastolic blood pressure, CVP central venous pressure, CRT capillary refill time, ScvO2 central venous oxygen saturation, Delta pCO2(v-a) difference between central venous carbon dioxide pressure and arterial carbon dioxide pressure