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Table 3 Logistic regression analysis with in-hospital death as the dependent variable in patients with ARDS

From: Temporal changes in the epidemiology, management, and outcome from acute respiratory distress syndrome in European intensive care units: a comparison of two large cohorts

 

Odds ratio (95% CI)

p value

Age (per year)

1.04 (1.03–1.04)

< 0.001

Male

0.81 (0.56–1.11)

0.235

SAPS II (per point)

1.04 (1.02–1.05)

< 0.001

Referring facility

 ER/ambulance

R

NA

 Hospital floor

0.89 (0.56–1.41)

0.618

 OR/recovery room

0.72 (0.42–1.23)

0.618

 Other hospital

0.77 (0.43–1.36)

0.367

 Others

0.96 (0.39–2.34)

0.923

Comorbidities

 No cancer

R

NA

 Solid cancer, non-metastatic

0.88 (0.49–1.56)

0.653

 Solid cancer, metastatic

2.90 (1.28–7.47)

0.027

 Cirrhosis

1.70 (0.70–4.11)

0.244

 Hematologic cancer

1.79 (0.75–4.23)

0.192

 Steroids

1.52 (0.73–3.16)

0.263

Polytrauma

0.47 (0.21–1.06)

0.263

Organ failure on admission to the ICU

 Coagulation

5.59 (2.74–11.41)

< 0.001

 Hepatic

1.07 (0.58–1.97)

0.830

 CNS

1.68 (1.14–2.48)

0.008

 Renal

1.82 (1.20–2.76)

0.005

 Cardiovascular

1.06 (0.73–1.53)

0.771

PaO2/FiO2 (per 20 mmHg)

0.99 (0.94–0.99)

< 0.001

Initial ventilatory settings

 Respiratory rate

1.01 (0.99–1.02)

0.863

 Tidal volume > 8.0 ml/kg PBW

0.68 (0.46–1.02)

0.157

 PEEP, cmH2O

  

  5–9

R

NA

  10–14

1.1 (0.66–1.81)

0.72

  ≥ 15

2.61 (0.56–12.19)

0.224

 Driving pressure > 14 cmH2O

1.64 (1.1–2.46)

0.016

 Plateau pressure > 29 cmH2O

1.04 (1.01–1.07)

0.006

  1. Excluding 96 patients with missing values and adjusted for country and study cohort (SOAP vs. ICON). Covariate inclusion in the final models was based on a univariate logistic regression analysis (p < 0.2) within the categories demographic variables (age and sex), comorbid conditions, severity of respiratory failure according to the PaO2/FiO2 ratio on the first day of mechanical ventilation, in addition to tidal volume and respiratory rate (Hosmer&Lemeshow goodness of fit Chi square: 5.49, p = 0.71; Nagelkerke’s R2 = 0.285). Patients who were excluded from the multivariable analysis due to missing variables (n = 96) had similar severity of respiratory failure as assessed by the PaO2/FiO2 ratio on the first day of mechanical ventilation and similar mortality rates compared to those who were included in the analysis
  2. CI confidence interval, CNS central nervous system, ER emergency room, ICU intensive care unit, OR operating room, PBW predicted body weight; PEEP positive end-expiratory pressure, SAPS Simplified Acute Physiology Score
  3. Introduced alternately in different models due to colinearity. The displayed values refer to those considered in the model that included the PEEP as a covariate. Changes in the pressure parameters did not influence the significant p-values of the other covariates