Outcomes | Anticipated absolute effects (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
---|---|---|---|---|---|---|
Late mobilization or standard early mobilization | Systematic early mobilization | |||||
MRC Sum Score (MRC-SS), measured at ICU discharge | (i) Systematic early vs. late mobilization | – | 104 (1 RCT) | ⨁⨁◯◯ LOWa,b | ||
The median MRC-SS in the comparator group was 48 (0 to 58) | The median MRC-SS in the intervention group was 52 (25 to 58) | |||||
(ii) Systematic early vs. standard early mobilization | – | 203 (4 RCTs) | ⨁◯◯◯ VERY LOWa,c,d | In a sensitivity analysis, omitting the study by Dantas et al. due to a high baseline imbalance in MRC-SS resulted in an MRC-SS in the intervention group, which was 2.2 higher (2.5 lower to 6.9 higher). For that result, the certainty of evidence is judged low (no serious inconsistency) | ||
The mean MRC-SS in the comparator group in studies ranged from 40.3 to 47.3 | The mean MRC-SS in the intervention group was 5.8 higher (1.4 lower to 13.0 higher) | |||||
Patients developing ICUAW, measured at hospital discharge | (i) Systematic early vs. late mobilization | RR 0.62 (0.38–1.03) | 104 (1 RCT) | ⨁⨁◯◯ LOWa,b | ||
49 per 100 | 31 per 100 | |||||
(ii) Systematic early vs. standard early mobilization | RR 0.90 (0.63–1.27) | 395 (3 RCTs) | ⨁◯◯◯ VERY LOWc,e | |||
39 per 100 | 36 per 100 | |||||
6-min Walk Test (6MWT), measured at various time points | (ii) Systematic early vs. standard early mobilization* | – | 232 (2 RCTs) | ⨁⨁◯◯ LOWa,f,g | ||
The mean 6MWT distance in the comparator group was 246 m in Eggmann et al. and 267 m in Denehy et al. at hospital discharge | The mean 6MWT distance in the intervention group was 223 in Eggmann et al. and 244.2 in Denehy et al. at hospital discharge | |||||
The mean change in 6MWT from baseline in the comparator group was 184.3 m at 3 months and 219.5 m at 6 months after hospital discharge in Denehy et al | The mean change in 6MWT from baseline in the intervention group was 63.7 m higher (14.2 to 113.2) at 3 months and 72.6 m higher (9.3 to 135.8) at 6 months in Denehy et al | |||||
Time to walking, measured during hospital stay | (i) Systematic early vs. late mobilization | – | 104 (1 RCT) | ⨁⨁◯◯ LOWa,b | ||
The median time to walking in the comparator group was 7.3 days (4.9 to 9.6) | The median time to walking in the intervention group was 3.8 days (1.9 to 5.8) | |||||
(ii) Systematic early vs. standard early mobilization | – | 53 (2 RCTs) | ⨁◯◯◯ VERY LOWa,c,h | |||
The median time to walking in the comparator group was 6 days in Hodgson et al. and 23 days in Eggmann et al | The median time to walking in the intervention group was 6 days in Hodgson et al. and 8 days in Eggmann et al | |||||
Patients returning to independence from assistance, measured at hospital discharge | (i) Systematic early vs. late mobilization* | RR 1.71 (1.11–2.64) | 104 (1 RCT) | ⨁⨁◯◯ LOWa,b | ||
35 per 100 | 59 per 100 | |||||
SF-36 Physical Function Domain Score (PFS), measured 6 months after hospital discharge | (i) Systematic early vs. late mobilization | – | 161 (1 RCT) | ⨁◯◯◯ VERY LOWa,b,c | ||
The mean SF-36 PFS in the comparator group was 43.6 | The mean SF-36 PFS in the intervention group was 12.3 higher (3.9 to 20.8) | |||||
(ii) Systematic early vs. standard early mobilization | – | 126 (2 RCTs) | ⨁◯◯◯ VERY LOWa,c,d,e | |||
The mean SF-36 PFS in the comparator group in studies ranged from 42.4 to 75.0 | The mean SF-36 PFS in the intervention group was 8.1 higher (15.3 lower to 31.4 higher) | |||||
SF-36 Physical Health Component Summary Score (PCS), measured 6 months after hospital discharge | (i) Systematic early vs. late mobilization | – | 161 (1 RCT) | ⨁◯◯◯ VERY LOWa,b,c | ||
The mean SF-36 PCS in the comparator group was 33.5 | The mean SF-36 PCS in the intervention group was 3.4 higher (0.01 higher to 6.8 higher) | |||||
(ii) Systematic early vs. standard early mobilization | – | 152 (2 RCTs) | ⨁◯◯◯ VERY LOWc,e | |||
The mean SF-36 PCS in the comparator group in studies ranged from 42.7 to 44.4 | The mean SF-36 PCS in the intervention group was 2.4 lower (6.1 lower to 1.3 higher) |