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Table 2 Global hemodynamic and transpulmonary thermodilution parameters. Comparison H0–H6

From: Hemodynamic and anti-inflammatory effects of early esmolol use in hyperkinetic septic shock: a pilot study

 

H0

H6

∆ H0–H6 (H6–H0)

p value**

Heart rate (bpm)

115 (110; 125)

100 (92; 103)

− 18 (− 25; − 15)

0.004

SAP (mmHg)

110 (102; 117)

103 (99; 104)

− 9 (− 14; 1)

0.16

DAP(mmHg)

54 (47; 55)

55 (54; 59)

4 (0; 8)

0.12

MAP (mmHg)

72 (68; 72)

72 (67; 75)

0 (− 3; 4)

0.52

Double product (mm Hg.bpm)

13,266 (12,138; 15,065)

9682 (8736; 10,609)

− 2657 (− 3305; − 2628)

0.008

CI(L/min/m2)

4.2 (3.1; 4.4)

2.9 (2.5; 3.7)

− 0.6 (− 1.2; − 0.5)

0.004

SVi (mL/m2)

29.8 (27.3; 37.8)

28.2 (27.2; 36.5)

− 0.2 (− 5.2; − 0.0)

0.25

CPI (W/m2

0.61 (0.54; 0.70)

0.48 (0.40; 0.58)

− 0.10 (− 0.17; − 0.06)

0.008

SVRi (dyn s m2 cm−5)

1164 (1143; 1412)

1379 (1333; 1876)

190 (139; 427)

0.004

CFI (1/min)

6.1 (4.8; 7.4)

3.7 (3.5; 4.8)

− 1.9 (− 2.6; − 1.0)

0.004

EPLW(mL/kg)

8 (7; 12)

9 (8; 11)

0 (− 1; 1)

0.91

CVP (mmHg)

8 (5; 8)

8 (6; 12)

1 (0; 2)

0.58

GEF (%)

20 (17; 21)

17 (15; 19)

− 3 (− 3; − 2)

0.004

Diuresis (mL/h)

100 (50; 150)

50 (10; 70)

− 60 (− 90; − 50)

0.016

SvcO2 (%)

73.6 (70.0; 87.0)

75.3 (71.0; 77.0)

− 3.5 (− 7.0; 3.5)

0.47

DO2i (ml/min/m−2)

444 (333; 615)

366 (319; 437)

− 68 (− 98; − 64)

0.031

VO2i (ml/min/m−2)

79 (61; 119)

93 (72; 96)

− 6 (− 13; 16)

0.84

Norepinephrine (µg/kg)

29.7 (20.2–50)

38.1 (18.1–66.5)

10.4 (5.7–25.5)

0.027

  1. HO O hours (baseline), H6 6 h, SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, Double product SAP x HR, CI cardiac index, SVi indexed stroke volume, CPI cardiac power index, SVRi indexed systemic vascular resistances, CFI cardiac function index, EPLW extra pulmonary lung water, CVP central venous pressure, GEF global ejection fraction, SvcO2 central venous oxygen saturation, DO2i indexed oxygen delivery, VO2i indexed oxygen consumption, norepinephrine = hourly amount of norepinephrine