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Fig. 2 | Critical Care

Fig. 2

From: The immune modulatory effects of mitochondrial transplantation on cecal slurry model in rat

Fig. 2

Effects of mitochondrial transplantation on sepsis in animal studies. a Conceptual figure of the rat sepsis model. b Kaplan–Meier survival plots of the studied animals (n = 16). **p < 0.01 and *p < 0.05 compared with the sepsis group. c The MFIs of MitoSOX and DCF-DA were measured in the spleen 24 h after induction of sepsis (top). Sham group, n = 3; sepsis and sepsis + MT mice, n = 9 per group). **p < 0.01 and *p < 0.05 compared with the sham group. ATP content and synthesis were measured in the spleen 24 h after induction of sepsis (bottom). Sham group, n = 3; sepsis and sepsis + MT group, n = 3 to 4 per group. ***p < 0.01 compared with the sham group and **p < 0.01 and *p < 0.05 compared with the sham and sepsis groups, respectively. d Oxygen consumption trace in muscle, spleen, liver, kidney and heart tissues. Spleen, n = 6 to 14 per group; muscle, n = 4 to 12 per group; liver, n = 10 to 13 per group; kidneys, n = 3 to 6 per group; heart, n = 2 to 6 per group. **p < 0.01 and *p < 0.05 compared with the sepsis group. e CFUs were counted in spleen and blood 24 h after induction of sepsis. Spleen, n = 5 to 14 per group; blood, n = 8 per group. *p < 0.05 compared with the sepsis group. f Lactate concentrations were assessed in plasma 24 h after induction of sepsis. Plasma, n = 10 per group. **p < 0.01 compared with the sepsis group. MT mitochondria, CFU colony-forming unit

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