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Table 1 Patients’ characteristics according to day-1 compliance of the respiratory system

From: Static compliance of the respiratory system in COVID-19 related ARDS: an international multicenter study

n = 372

Crs < 35.4

n = 186

Crs > 35.4

n = 186

P valuea

Age, mean ± SD

63.5 ± 10

63.2 ± 10.8

0.78

Gender, men, n (%)

130 (70)

154 (83)

0.005

Body mass index, kg/m2, mean ± SD

29.9 ± 5.1

29.5 ± 5

0.47

Hypertension, n (%)

116 (62)

94 (51)

0.02

Pulmonary chronic disease, n (%)

24 (13)

26 (14)

0.88

Charlson comorbidity index, median (IQR)

1 (0–2)

1 (0–2)

0.18

Charlson comorbidity index

  

0.11

 0

69 (37)

86 (46)

 

 1

53 (29)

38 (20)

 

  ≥ 2

64 (34

62 (33)

 

Time from symptoms onset, days, median (IQR)

7 (5–10)

8 (5–10)

0.02

Coinfection, n (%)

19 (10)

23 (12)

0.62

PaO2/FiO2 (mmHg), mean ± SD

123 ± 48

132 ± 53

0.07

Tidal volume (ml/kg IBW), mean ± SD

n = 180/185

6.2 ± 0.9

6.3 ± 0.8

0.12

PEEP (cmH2O), mean ± SD

11.1 ± 2.9

12 ± 2.6

0.002

Plateau pressure (cmH2O), median (IQR)

26 (23–28)

22 (20–24)

 < 0.001

Driving Pressure (cmH2O), median (IQR)

14 (12–16)

9.5 (8–11)

 < 0.001

Inhaled nitric oxide, n (%)

21 (11)

23 (12)

0.87

Prone positioning, n (%)

152 (82)

147 (79)

0.51

Neuromuscular blocking agents, n (%)

162 (87)

151 (81)

0.16

Antiviral treatment, n (%)

143 (77)

158 (85)

0.06

Corticosteroidsb, n (%)

n = 175/182

34 (19)

43 (24)

0.37

Macrolides

112 (60)

116 (62)

0.75

  1. SD standard deviation, IQR interquartile range, IBW ideal body weight; Crs static compliance of the respiratory system
  2. aP value was calculated by Fisher exact test, t test or Mann–Whitney test as appropriate
  3. bSome patients were included in a RCT steroids versus placebo, steroids were mostly given late in the ICU stay