Table 4 Association between administration of sodium bicarbonate and clinical outcomes
|  | Overall population (N = 360) |  |  | Vasopressor dependent at the diagnosis of metabolic acidosis (N = 187) |  |  | Severe metabolic acidosis at the time of diagnosis (N = 46) |  |  |
|---|---|---|---|---|---|---|---|---|---|
|  | aOR, β | 95% CI | p Value | aOR, β | 95% CI | p Value | aOR, β | 95% CI | p Value |
ICU mortality | 0.85 | 0.44 to 1.62 | 0.63 | 0.52 | 0.22 to 1.19 | 0.13 | 0.86 | 0.08 to 9.03 | 0.90 |
Hospital mortality | 0.96 | 0.51 to 1.76 | 0.89 | 0.84 | 0.38 to 1.85 | 0.68 | 1.07 | 0.09 to 12.3 | 0.96 |
Vasopressor dose at 6 h | –0.02 | –0.08 to 0.03 | 0.36 | 0.01 | –0.07 to 0.09 | 0.81 | –0.23 | –0.50 to 0.03 | 0.11 |
Vasopressor dose at 24 h | 0.04 | –0.01 to 0.08 | 0.10 | 0.04 | –0.03 to 0.11 | 0.24 | –0.004 | –0.16 to 0.16 | 0.97 |
Mean arterial pressure at 6 h | 2.85 | –0.50 to 6.15 | 0.09 | 5.99 | 1.84 to 10.2 | 0.01 | 6.60 | –3.65 to 17.2 | 0.23 |
Mean arterial pressure at 24 h | –1.07 | –4.28 to 2.13 | 0.52 | –1.03 | –5.21 to 3.15 | 0.63 | 8.90 | –1.44 to 19.2 | 0.13 |
Delta mean arterial pressure per vasopressor dose at 6 h | 3.66 | –0.78 to 8.09 | 0.11 | 8.87 | 3.34 to 14.48 | 0.002 | 8.53 | –8.60 to 25.4 | 0.35 |
Delta mean arterial pressure per vasopressor dose at 24 h | 1.26 | –3.68 to 6.22 | 0.28 | 3.65 | –2.56 to 9.88 | 0.26 | 13.7 | 0.79 to 26.6 | 0.06 |