Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial

Table 2 Primary and secondary outcomes (ITT analysis)

	n	Intervention (n = 201)	n	Control (n = 198)	P
Primary endpoint
Post-ICU LOS (days)	201	33 (13; 90)	198	33 (11; 90)	0.78
Secondary outcomes
Day 15 Hb (g/dL)	127	10.3 ± 1.7	119	10.30 ± 1.5	0.81
Day 15 hepcidin (µg/L)	69	34.6 (17.4; 53.7)	68	27.7 (11.9; 62.7)	0.63
Day 30 fatigue (scale 1–10)	120	5 (3; 6)	114	5 (3; 7)	0.44
Day 30 MFI-20,	126		120
General fatigue (score 9–45)	126	27 (18; 31)	120	24.5 (18; 30)	0.41
Mental fatigue (score 6–30)	126	24 (20; 28)	120	26 (21; 29)	0.26
Reduced activity (score 3–15)	126	8 (6; 10)	120	8 (6; 11)	0.66
Reduced motivation (score 2–10)	126	8 (6; 10)	120	8 (6; 10)	0.72
Deaths at day 90	201	16 (8.0)	198	33 (16.67)	0.008

Data are expressed as mean ± SD, median(Q1; Q3) or n(%)
Italics were used to indicate sub-headings in the tables and p-values
Somme data are missing (i.e., Hb concentrations at D15, fatigue assessment at D30), in that cases the number of available data is indicated. ITT intention to treat, ICU intensive care unit, LOS length of stay, Hb hemoglobin, MFI-20 multidimensional fatigue inventory

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