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Table 1 Patients characteristics according to the study group

From: Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial

 

Intervention (n = 201)

Control (n = 198)

p

Age (years)

63.4 ± 14.8

63.1 ± 14.3

0.77

Women

60 (31.1)

65 (33.5)

0.67

BMI (kg/m2)

27.7 (23.4; 32.8)

27.1 (24.1; 30.8)

0.81

At least one chronic disease

160 (79.6)

157 (79.3)

0.94

Diabetes

42 (26.3)

60 (38.2)

0.023

Cirrhosis

12 (7.5)

18 (11.6)

0.21

Heart failure

13 (8.2)

14 (8.9)

0.79

Arterial hypertension

106 (66.3)

93 (59.6)

0.22

Coronary artery disease

26 (16.3)

18 (11.6)

0.23

Chronic renal failure

13 (8.1)

13 (8.3)

0.95

COPD

23 (14.4)

21 (13.5)

0.81

Mc CABE score

  

0.21

Non-fatal

140 (71.8)

143 (74.1)

 

Ultimately fatal (1–4 years)

47 (24.1)

36 (18.7)

 

Rapidly fatal (< 1 year)

8 (4.1)

14 (7.3)

 

ICU admission

   

Recent surgical history

122 (60.7)

123 (62.1)

0.77

Sepsis on admission

72 (35.8)

75 (37.9)

0.67

Significant bleeding on admission

35 (17.4)

37 (18.7)

0.74

Transfusion before inclusion*

92 (45.8)

90 (44.5)

0.95

SAPS II

38 (29; 51)

41 (27; 55)

0.49

SOFA

6 (4; 9)

7 (4; 10)

0.14

Hb (g/dL)

11.1 ± 2.2

11.2 ± 2.7

0.98

Organ support during ICU stay

   

ICU LOS (days)

13 (7; 22)

12 (7; 20)

0.89

Mechanical ventilation

158 (78.6)

160 (80.8)

0.58

 Duration of MV (days)

4 (2; 12)

5 (2; 12)

0.86

Renal support

31 (15.4)

26 (13.1)

0.51

 Duration of support (days)

7 (2; 14)

4 (2; 13)

0.34

Catecholamine

129 (64.2)

133 (67.2)

0.53

 Duration of catecholamine (days)

3 (2; 5)

3 (2; 5)

0.68

ICU discharge blood tests

   

Hb (g/dL)

10.0 (9.1; 10.8)

9.7 (8.8; 10.7)

0.12

CRP (mg/L)

66.0 (39.0; 102.9)

69.0 (34.0; 128.0)

0.82

Ferritin (µg/L)

710 (363; 1201)

584 (286; 903)

0.16

TSAT (%)

14 (10; 22)

14 (12; 19)

0.84

Hepcidin (µg/L)

31.10 (13.35; 56.25)

33.70 (13.55; 65.45)

0.67

Absolute ID (n)

71 (35.3)

65 (32.8)

0.47

Functional ID (n)

37 (18.4)

47 (23.7)

0.29

  1. Data are expressed as mean ± SD, median(Q1;Q3) or n(%)
  2. BMI Body Mass Index, COPD chronic obstructive pulmonary disease, ICU intensive care unit, SAPS II Simplified Acute Physiology Score II, SOFA Simplified Organ Failure Assessment, Hb hemoglobin, LOS length of stay, MV mechanical ventilation, CRP C reactive protein, TSAT transferrin saturation. Absolute ID Absolute iron deficiency was defined as an hepcidin < 20 µg/L; Functional ID functional iron deficiency was defined as 20 ≤ hepcidin < 41 µg/L
  3. *Transfusion before inclusion is defined as having received a blood transfusion during the week before inclusion
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Critical Care

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