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Table 3 Association between corticosteroid therapy and day-90 Mortality or SARS-CoV-2 RNA Clearance

From: Corticosteroid therapy in critically ill patients with COVID-19: a multicenter, retrospective study

  Day-90 mortality SARS-CoV-2 RNA clearance
Logistic regression Cox proportional hazards regression model Marginal structural model Cox proportional hazards regression model Marginal structural model
OR 95%CI p value HR 95%CI p value OR 95%CI p value HR 95%CI p value OR 95%CI p value
Corticosteroids versus no corticosteroids 0.15 0.00, 2.59 0.22 1.37 0.54, 3.47 0.51 1.37 0.93, 2.02 0.11 1.10 0.36, 3.37 0.86 0.85 0.63, 1.17 0.33
> 300 mg/day versus no corticosteroidsa NA NA NA 0.62 0.12, 3.26 0.57 1.01 0.62, 1.64 0.98 0.81 0.10, 6.38 0.84 0.67 0.44, 1.02 0.062
≤ 300 mg/day versus no Corticosteroidsa 1.44 0.71, 2.96 0.31 1.42 0.94, 2.15 0.099 1.42 0.93, 2.17 0.1 0.91 0.22, 3.74 0.89 0.95 0.68, 1.34 0.78
3 day initiation versus no corticosteroidsb 1.08 0.56, 2.12 0.81 1.06 0.70, 1.59 0.8 1.11 0.75, 1.66 0.6 0.91 0.65, 1.25 0.55 0.85 0.62, 1.17 0.33
≤ 3 day initiation versus no corticosteroidsb 4.49 1.17, 17.25 0.025 3.89 1.94, 7.82 < 0.001 2.32 1.16, 4.65 0.017 0.26 0.13, 0.54 < 0.001 0.81 0.43, 1.52 0.5
  1. HR hazard ratio, OR odds ratio, CI confidence interval, MSM marginal structural model, NA not available
  2. a300 mg/day means hydrocortisone equivalents per ICU day
  3. b> 3 day or ≤ 3 day means initiation of corticosteroids in more than 3 or less than 3 days after ICU admission