Table 2 Ventilator settings, clinical variables, and outcomes as a function of mechanical power during ECMO
Variables | MP during the first 3Â days of ECMO | p | |
|---|---|---|---|
High (n = 41) (> 14.4 J/min) | Low (n = 111) (≤ 14.4 J/min) | ||
Ventilator settings before ECMO | Â | Â | Â |
 MP (J/min) | 25.0 ± 9.5 | 23.3 ± 9.5 | 0.339 |
 MP/PBW (× 10−3 J/min/kg) | 441 ± 166 | 408 ± 172 | 0.316 |
 MP/Compliance (J/min/ml/cm H2O) | 1.32 ± 0.71 | 1.26 ± 0.78 | 0.672 |
 Tidal volume (ml/kg PBW) | 8.3 ± 2.3 | 7.5 ± 2.4 | 0.062 |
 PEEP (cm H2O) | 11.9 ± 2.7 | 12.0 ± 2.8 | 0.786 |
 Peak inspiratory pressure (cm H2O) | 34.4 ± 6.5 | 33.8 ± 6.5 | 0.568 |
 Mean airway pressure (cm H2O) | 19.2 ± 3.9 | 18.4 ± 4.5 | 0.310 |
 Dynamic compliance (ml/cm H2O) | 22.3 ± 8.4 | 22.7 ± 12.1 | 0.869 |
 Total respiratory rate (breaths/min) | 23.9 ± 6.7 | 24.0 ± 7.1 | 0.891 |
 Spontaneous respiratory rate (breaths/min) | 1 (0–6) | 0 (0–7) | 0.956 |
 Minute ventilation (L/min) | 11.2 ± 3.5 | 10.3 ± 3.9 | 0.205 |
Arterial blood gas before ECMO | Â | Â | Â |
 pH | 7.24 ± 0.16 | 7.29 ± 0.13 | 0.056 |
 PaCO2 (mm Hg) | 56.1 ± 20.0 | 51.1 ± 18.4 | 0.150 |
 PaO2 (mm Hg) | 72.4 ± 33.4 | 74.5 ± 41.7 | 0.776 |
 Saturation (%) | 83.2 ± 17.4 | 85.1 ± 14.4 | 0.508 |
 PaO2/FiO2 (mm Hg) | 66.5 (49.7–85.7) | 63 (53–90.7) | 0.882 |
SOFA score before ECMO | 11.9 ± 3.1 | 10.4 ± 3.1 | 0.013 |
Ventilator settings from day 1 to day 3 on ECMO | Â | Â | Â |
 MP (J/min) | 20.3 ± 5.3 | 9.1 ± 3.0 | < 0.001 |
 MP/PBW (× 10−3 J/min/kg) | 343 ± 117 | 159 ± 55 | < 0.001 |
 MP/Compliance (J/min/ml/cm H2O) | 1.14 ± 0.48 | 0.59 ± 0.35 | < 0.001 |
 Tidal volume (ml/kg PBW) | 7.4 ± 2.2 | 5.6 ± 2.0 | < 0.001 |
 PEEP (cm H2O) | 11.8 ± 2.5 | 12.0 ± 3.5 | 0.653 |
 Peak inspiratory pressure (cm H2O) | 35.2 ± 5.4 | 30.5 ± 5.1 | < 0.001 |
 Mean airway pressure (cm H2O) | 19.6 ± 3.8 | 17.0 ± 3.8 | < 0.001 |
 Dynamic compliance (ml/cm H2O) | 19.9 ± 6.5 | 18.9 ± 8.5 | 0.520 |
 Total respiratory rate (breaths/min) | 20.3 ± 5.4 | 14.4 ± 3.5 | < 0.001 |
 Spontaneous respiratory rate (breaths/min) | 4 (1–9) | 0 (0–3) | < 0.001 |
 Minute ventilation (L/min) | 8.9 ± 2.5 | 4.5 ± 1.6 | < 0.001 |
Arterial blood gas from day 1 to day 3 on ECMO | Â | Â | Â |
 pH | 7.42 ± 0.08 | 7.44 ± 0.08 | 0.286 |
 PaCO2 (mm Hg) | 38.6 ± 6.5 | 38.1 ± 4.7 | 0.639 |
 PaO2 (mm Hg) | 102.2 ± 65.9 | 96.1 ± 39.5 | 0.489 |
 Saturation (%) | 94.8 ± 3.3 | 95.5 ± 2.9 | 0.240 |
 PaO2/FiO2 (mm Hg) | 151 (123–212) | 189 (140–242) | 0.921 |
SOFA score from day 1 to day 3 on ECMO | 10.7 ± 2.2 | 9.2 ± 2.2 | 0.001 |
ECMO complications, n (%) | 9 (22%) | 34 (30.6%) | 0.292 |
Duration of ECMO (days) | 7.7 (4.7–11.5) | 9.9 (5.9–15.8) | 0.287 |
Duration of mechanical ventilator (days) | 15.4 (11.8–34) | 22.9 (12.4–39.8) | 0.291 |
Length of ICU stay (days) | 19 (10–43) | 27 (16–43) | 0.182 |
Length of hospital stay (days) | 29 (13–63) | 41 (24–65.5) | 0.130 |
ECMO-free days on day 28 | 0 (0–18.2) | 10.1 (0–19.3) | 0.075 |
Ventilator-free days on day 28 | 0 (0–0) | 0 (0–8.5) | 0.311 |
Ventilator-free days on day 60 | 0 (0–20.4) | 8.3 (0–40.5) | 0.04 |
Hospital mortality, n (%) | 29 (70.7%) | 52 (46.8%) | 0.004 |