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Table 2 Prediction of inotropic and respiratory support and thrombocytopenia

From: Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates

 

Total population (n = 480)

Interleukin-6

Procalcitonin

C-reactive protein

Inotropic support

N = 67 cases (14%)

   

AUC

 

0.71

0.79

0.65

95% CI

 

0.63–0.80

0.63–0.80

0.56–0.73

Exploratory cutoff

 

118 pg/mL

1.03 ng/mL

6.3 mg/L

Sensitivity

 

63.1%

79.6%

58.9%

Specificity

 

77.8%

71.1%

65.7%

Thrombocytopenia

N = 79 cases (16.5%)

   

AUC

 

0.77

0.83

0.79

95% CI

 

0.67–0.88

0.72–0.93

0.69–0.89

Exploratory cutoff

 

391 pg/mL

1.89 ng/mL

11.0 mg/L

Sensitivity

 

60.0%

79.2%

80.0%

Specificity

 

88.1%

82.3%

72.6%

 

Total population (n = 401)

   

Respiratory support

N = 68 cases (17%)

   

AUC

 

0.67

0.72

0.59

95% CI

 

0.60–0.74

0.65–0.80

0.51–0.67

Exploratory cutoff

 

201 pg/mL

1.6 ng/mL

27 mg/L

Sensitivity

 

39.7%

45.3%

23.9%

Specificity

 

85.6%

85.8%

86.9%

  1. Data represent AUC values with their respective 95% confidence intervals, exploratory cutoff points with sensitivity and specificity for each biomarker