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Table 3 Qualitative assessment of results of metanalysis for use of ECMO in children with sepsis (GRADE analysis)

From: Role of extracorporeal membrane oxygenation in children with sepsis: a systematic review and meta-analysis

â„– of studies

Certainty assessment

Effect

Certainty

Importance

Study design

Risk of bias

Inconsistency

Indirectness

Imprecision

Other considerations

â„– of events

â„– of individuals

Rate (95% CI)

Overall survival during ECMO in children with sepsis

           

13

Observational studies

Not serious

Serious a

Not serious

Not serious

None

1317

2559

0.59 (0.51 to 0.67)

⊕⊕⊕О MODERATE

CRITICAL

VA-ECMO survival in children with sepsis

           

9

Observational studies

Not serious

Not serious

Not serious

Not serious

None

118

208

0.65 (0.50 to 0.80)

⊕⊕⊕⊕ HIGH

CRITICAL

ECMO survival in pediatric group with sepsis

           

6

Observational studies

Not serious

Not serious

Not serious

Not serious

None

69

138

0.50 (0.41 to 0.59)

⊕⊕⊕⊕ HIGH

CRITICAL

ECMO survival in Neonatal sepsis

           

7

Observational studies

Not serious

Not serious

Not serious

Not serious

None

59

85

0.73 (0.56 to 0.87)

⊕⊕⊕⊕ HIGH

CRITICAL

  1. aThere was considerable amount of heterogenity of I2 = 62% even after statistical removal of potential outliers that could have contributed to heterogenity, likely explained by the differences in age groups( neonate Vs pediatric), sample size and variability in JBI scores