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Table 5 Predictors of Adverse Event in Patients With COVID-19 by Cox Proportional Hazard Model

From: Prognostic value of bedside lung ultrasound score in patients with COVID-19

Variables

Univariate Cox regression

Model 1

Age + Lymphocytes% + Comorbidity

Model 2

Age + Lymphocytes% + Comorbidity + LUS score

Model 3

Age + Lymphocytes% + Comorbidity + LUS score > 12

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age, years

1.081 (1.057, 1.106)

 < 0.001

1.040 (1.011, 1.070)

0.007

1.032 (1.001, 1.063)

0.041

1.028 (0.999, 1.059)

0.06

Male (yes vs. no)

1.074 (0.558, 2.068)

0.83

      

BMI, Kg/m [2]

0.828 (0.622, 1.103)

0.197

      

Lymphocytes%

0.872 (0.836, 0.909)

 < 0.001

0.892 (0.853, 0.932)

 < 0.001

0.937 (0.892, 0.985)

0.01

0.940 (0.897, 0.985)

0.01

CRP, mg/L

1.007 (1.002, 1.012)

0.01

      

hs-TnI, ng/L

1.000 (1.000, 1.001)

0.004

      

CK-MB, U/L

1.004 (1.001, 1.008)

0.022

      

Comorbidity (yes vs. no)

4.928 (2.417, 10.050)

 < 0.001

0.994 (0.453, 2.182)

0.987

0.545 (0.228, 1.299)

0.171

0.695 (0.316, 1.528)

0.366

LUS score

1.083 (1.065, 1.100)

 < 0.001

  

1.049 (1.023, 1.076)

 < 0.001

  

LUS score > 12 (yes vs. no)

49.935 (15.296, 163.016)

 < 0.001

    

10.760 (2.753, 42.049)

0.001

AIC

  

286

 

272

 

272

 

C-index

  

0.866

 

0.903

 

0.902

 
  1. P < 0.05 was considered statistically significant. AIC, Akaike information criterion; C-index, concordance index; CK-MB, creatine kinase muscle-brain; CRP, C-reactive protein; hs-TnI, hypersensitive troponin I; CI, confidence interval; HR, hazard ratio