Electrical impedance tomography to titrate positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome

Table 2 Comparison of respiratory mechanics and PEEP titration in supine position, for patients with acute respiratory distress syndrome induced or not by coronavirus disease-19

	C-ARDS (n = 17)	NC-ARDS (n = 13)	p value
Respiratory mechanics
Respiratory rate (breath/min)	30 [28, 35]	31 [29, 31]	0.74
Tidal volume (ml/kg of PBW)	6.1 [5.9, 6.3]	6.2 [6.0, 6.3]	0.58
C_RS at low PEEP (mL/cmH₂O)	40 [32, 47]	35 [26, 38]	0.07
Airway opening pressure (cmH₂O)	2 [0, 4]	NA
Recruitment-to-inflation ratio	0.46 [0.33, 0.52]	NA
PaO₂/FiO₂ before EIT explorations (mmHg)	133 [96, 180]	120 [110, 137]	0.40
EIT-PEEP titration
Best PEEP^a (cmH₂O)	12 [9, 12]	9 [6, 9]	< 0.01
Hyperdistension at PEEP 18 cmH₂O, %	24 [17, 30]	35 [25, 41]	0.02
AUC for hyperdistension	111 [68, 136]	193 [119, 226]	0.03
Collapse at PEEP 6 cmH₂O, %	27 [20, 35]	13 [7, 19]	< 0.01
AUC for collapse	94 [59, 141]	45 [31, 61]	< 0.01

^aDefined using EIT as the smallest sum of hyperdistension and collapse. Continuous variables are expressed as median [interquartile range]
C-ARDS coronavirus disease-19-related acute respiratory distress syndrome, NC-ARDS noncoronavirus disease-19-related acute respiratory distress syndrome, PBW predicted body weight, C_RS respiratory system compliance, PEEP positive end-expiratory pressure, EIT electrical impedance tomography, AUC area under the curve, NA not available

ISSN: 1364-8535