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Table 2 Logistic regression and competing risk regression assessing association of CHOP ARDS Transcriptomic Subtypes (CATS) clusters and PICU mortality or probability of extubation by day 28 (accounting for the competing risk of death)

From: Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome

 

PICU mortality

Probability of extubation

OR (95% CI)a

p value

SHR (95% CI)b

p value

Unadjusted

    

 CATS-1

Ref

–

Ref

–

 CATS-2

0.67 (0.21–2.08)

0.487

1.01 (0.54–1.91)

0.967

 CATS-3

0.19 (0.05–0.78)

0.021

2.15 (1.26–3.64)

0.005

Adjusted for PRISM III

 CATS-1

Ref

–

Ref

–

 CATS-2

0.53 (0.16–1.76)

0.300

1.14 (0.60–2.17)

0.686

 CATS-3

0.13 (0.03–0.60)

0.009

2.83 (1.55–5.17)

0.001

Adjusted for immunocompromised

 CATS-1

Ref

–

Ref

–

 CATS-2

0.44 (0.12–1.58)

0.207

1.20 (0.66–2.18)

0.557

 CATS-3

0.24 (0.06–1.07)

0.061

1.74 (1.02–3.00)

0.044

Adjusted for PRISM III + immunocompromised

    

 CATS-1

Ref

–

Ref

–

 CATS-2

0.35 (0.09–1.36)

0.130

1.35 (0.74–2.44)

0.329

 CATS-3

0.18 (0.04–0.86)

0.031

2.39 (1.32–4.32)

0.004

Adjusted for PRISM + immunocompromised + ANC

 CATS-1

Ref

–

Ref

–

 CATS-2

0.28 (0.07–1.14)

0.074

1.44 (0.78–2.67)

0.247

 CATS-3

0.11 (0.02–0.60)

0.011

2.77 (1.38–5.57)

0.004

Adjusted for PRISM + immunocompromised + ALC

 CATS-1

Ref

–

Ref

–

 CATS-2

0.42 (0.10–1.67)

0.221

1.25 (0.69–2.27)

0.456

 CATS-3

0.19 (0.04–0.90)

0.036

2.37 (1.32–4.25)

0.004

  1. ALC absolute lymphocyte count, ANC absolute neutrophil count, PRISM III Pediatric Risk of Mortality III
  2. aOdds ratio (OR) < 1: lower odds of mortality
  3. bSubdistribution hazard ratio (SHR) > 1: greater hazard for extubation alive (i.e., shorter duration of ventilation)