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Table 1 Demographics stratified by CHOP ARDS Transcriptomic Subtypes (CATS)

From: Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome

Variables

CATS-1 (n = 31)

CATS-2 (n = 29)

CATS-3 (n = 36)

p value

Age (years)

6.8 [1.2, 13]

14.1 [6.9, 16.5]

7 [1.8, 12.8]

0.006

Female (%)

13 (42)

12 (42)

13 (36)

0.898

Severity of illness

    

 PRISM III at 12 h

9 [5, 15]

13 [8, 18]

12 [7, 21]

0.278

 Nonpulmonary organ failures

2 [1, 3]

1 [1, 2]

1 [1, 2]

0.530

 Vasopressor score

10 [4, 18]

5 [0, 12]

7 [0, 28]

0.313

Comorbidities (%)

    

 Immunocompromised

10 (32)

14 (48)

5 (14)

0.011

 Stem cell transplant

4 (13)

8 (28)

2 (6)

0.040

Cause of ARDS (%)

    

 Direct

22 (71)

23 (79)

25 (69)

0.652

 Indirect

9 (29)

6 (21)

11 (31)

 

Cause of ARDS (%)

    

 Infectious

21 (68)

25 (86)

29 (81)

0.211

 Noninfectious

10 (32)

4 (14)

7 (19)

 

Cause of ARDS (%)

    

 Infectious pneumonia

16 (52)

19 (66)

21 (58)

 

 Nonpulmonary sepsis

5 (16)

6 (21)

8 (22)

 

 Aspiration pneumonia

4 (13)

3 (10)

3 (8)

0.606

 Trauma

1 (3)

1 (3)

1 (3)

 

 Other

5 (16)

0

3 (8)

 

ARDS onset

    

 PaO2/FIO2

152 [88, 243]

148 [121, 222]

138 [85, 187]

0.450

 OI

11.1 [6.7, 18.1]

11 [8.7, 13.4]

13.5 [9.6, 23.9]

0.371

24 h after onset

    

 PaO2/FIO2

179 [130, 240]

236 [182, 292]

252 [186, 323]

0.002

 OI

9.8 [6.2, 14.3]

5.7 [4.8, 8.1]

6 [4.3, 10.6]

0.004

Outcomes

    

 Ventilator days (all)

7 [5, 12]

10 [5, 24]

6 [4, 10]

0.152

 Ventilator days (survivors)

7 [6, 12]

9 [5, 16]

6 [4, 10]

0.201

 VFDs at 28 days

16 [0, 22]

16 [0, 21]

22 [12, 24]

0.012

 PICU mortality (%)

10 (32)

7 (24)

3 (8)

0.039

  1. ARDS acute respiratory distress syndrome, OI oxygenation index, PRISM III Pediatric Risk of Mortality III, VFDs ventilator-free days