From: Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome
Variables | CATS-1 (n = 31) | CATS-2 (n = 29) | CATS-3 (n = 36) | p value |
---|---|---|---|---|
Age (years) | 6.8 [1.2, 13] | 14.1 [6.9, 16.5] | 7 [1.8, 12.8] | 0.006 |
Female (%) | 13 (42) | 12 (42) | 13 (36) | 0.898 |
Severity of illness | Â | Â | Â | Â |
 PRISM III at 12 h | 9 [5, 15] | 13 [8, 18] | 12 [7, 21] | 0.278 |
 Nonpulmonary organ failures | 2 [1, 3] | 1 [1, 2] | 1 [1, 2] | 0.530 |
 Vasopressor score | 10 [4, 18] | 5 [0, 12] | 7 [0, 28] | 0.313 |
Comorbidities (%) | Â | Â | Â | Â |
 Immunocompromised | 10 (32) | 14 (48) | 5 (14) | 0.011 |
 Stem cell transplant | 4 (13) | 8 (28) | 2 (6) | 0.040 |
Cause of ARDS (%) | Â | Â | Â | Â |
 Direct | 22 (71) | 23 (79) | 25 (69) | 0.652 |
 Indirect | 9 (29) | 6 (21) | 11 (31) |  |
Cause of ARDS (%) | Â | Â | Â | Â |
 Infectious | 21 (68) | 25 (86) | 29 (81) | 0.211 |
 Noninfectious | 10 (32) | 4 (14) | 7 (19) |  |
Cause of ARDS (%) | Â | Â | Â | Â |
 Infectious pneumonia | 16 (52) | 19 (66) | 21 (58) |  |
 Nonpulmonary sepsis | 5 (16) | 6 (21) | 8 (22) |  |
 Aspiration pneumonia | 4 (13) | 3 (10) | 3 (8) | 0.606 |
 Trauma | 1 (3) | 1 (3) | 1 (3) |  |
 Other | 5 (16) | 0 | 3 (8) |  |
ARDS onset | Â | Â | Â | Â |
 PaO2/FIO2 | 152 [88, 243] | 148 [121, 222] | 138 [85, 187] | 0.450 |
 OI | 11.1 [6.7, 18.1] | 11 [8.7, 13.4] | 13.5 [9.6, 23.9] | 0.371 |
24Â h after onset | Â | Â | Â | Â |
 PaO2/FIO2 | 179 [130, 240] | 236 [182, 292] | 252 [186, 323] | 0.002 |
 OI | 9.8 [6.2, 14.3] | 5.7 [4.8, 8.1] | 6 [4.3, 10.6] | 0.004 |
Outcomes | Â | Â | Â | Â |
 Ventilator days (all) | 7 [5, 12] | 10 [5, 24] | 6 [4, 10] | 0.152 |
 Ventilator days (survivors) | 7 [6, 12] | 9 [5, 16] | 6 [4, 10] | 0.201 |
 VFDs at 28 days | 16 [0, 22] | 16 [0, 21] | 22 [12, 24] | 0.012 |
 PICU mortality (%) | 10 (32) | 7 (24) | 3 (8) | 0.039 |