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Table 1 Patients’ characteristics in the high flow nasal therapy (HFNT) and noninvasive ventilation (NIV) groups at baseline

From: High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial

  HFNT group NIV group p value
N 40 39  
Females, n (%) 19 (47.5) 20 (51.3) 0.7368
Age (years), mean ± SD 74 ± 13 77. ± 12 0.2273
Weight (kg)a, mean ± SD 85 ± 23 76 ± 13 0.0964
Height (m)a, mean ± SD 1.7 ± 0.1 1.7 ± 0.1 0.5494
BMI (kg/m2)a, mean ± SD 30.5 ± 8.7 26.7 ± 5.5 0.0622
Ward of admission, n (%)    0.5807
 Emergency room 24 (60) 21 (53.8)  
 ICU or respiratory unit 16 (40) 18 (46.1)  
SAPS II, mean ± SD 30 ± 9 33 ± 10 0.1497
Charlson index, mean ± SD 4 ± 2 5 ± 3 0.4709
Systolic blood pressure (mmHg), mean ± SD 131 ± 27 137 ± 24 0.3629
Diastolic blood pressure (mmHg), mean ± SD 71 ± 17 70 ± 13 0.7089
Heart rate (per min), mean ± SD 91 ± 20 92 ± 19 0.9609
Respiratory rate (per min), mean ± SD 27 ± 7 28 ± 7 0.5544
Body temperatureb (C°), mean ± SD 36.6 ± 0.7 36.8 ± 0.5 0.0489
Kelly Matthay score, n (%)    0.0694
 Alert, follows complex command (1) 19 (47.5) 25 (64.1)  
 Alert, follows simple commands (2) 9 (22.5) 8 (20.5)  
 Lethargie (3) 12 (30) 4 (10.3)  
 Stuporous (4) 0 (0) 2 (5.1)  
Borg dyspnea scoreb, mean ± SD 5 ± 2 5 ± 2 0.4463
RASS, n (%)    0.4813
 Light sedation (− 2) 2 (5) 2 (5.1)  
 Drowsy (− 1) 13 (32.5) 7 (17.9)  
 Alert and calm (0) 21 (52.5) 26 (66.7)  
 Restless (+ 1) 4 (10) 4 (10.3)  
Secretion, n (%)    0.2163
 Normal 23 (57.5) 17 (43.6)  
 Abundant 17 (42.5) 22 (56.4)  
PaCO2 (mmHg), mean ± SD 73.7 ± 12.8 72.0 ± 13.0 0.5270
Arterial pH, mean ± SD 7.30 ± 0.03 7.29 ± 0.03 0.7450
PaO2 (mmHg), mean ± SD 64.3 ± 17.6 73.3 ± 27.9 0.1480
SpO2 (%), median [IQR] 90.1 [87.0–94.1] 92.0 [88.0–96.0] 0.1835
HCO3− (mmol L−1), mean ± SD 34.3 ± 5.9 33.1 ± 6.30 0.3680
PaO2/FiO2, mean ± SD 203.2 ± 45.5 222.4 ± 71.0 0.4801
Lactatec (mmol L−1), median [IQR] 1.1 [0.7–1.6] 1.1 [0.9–1.5] 0.7376
  1. BMI body mass index, FiO2 fraction of inspired oxygen, HCO3− bicarbonate, HFNT high-flow nasal therapy, ICU intensive care unit, IQR interquartile range (first and third quartile), NIV noninvasive ventilation, PaO2arterial partial pressure, PaCO2 partial pressure of carbon dioxide, RASS Richmond agitation-sedation scale, SAPS simplified acute physiology score, SD standard deviation
  2. aData was not available for five patients (three in HFNT and two NIV group)
  3. bData was not available for one patient in NIV group
  4. cData was not available for one patient in HFNT group
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Critical Care

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