Table 2 Laboratory parameters of total cohort and subcohorts with and without thromboembolic events

Laboratory variables (normal values)

 Haemoglobin (12·5–17·2 g/dL)

10.1

[8.5–11.2]

9.70

[8.3–10.8]

10.4

[9.3–11.9]

ns

 White blood cells (3·5–10·5/nl)

10.13

[7.5–13.7]

10.63

[7.4–16]

9.58

[6.6–12.1]

ns

 Platelet count (150–370/nl)

193.5

[131.3–316.3]

181

[116–306]

209

[178–325.5]

ns

 Prothrombin time (70–130%)

74.5

[62.8–86]

79

[61–83]

71

[63.5–87.5]

ns

 INR (0·9–1·25)

1.2

[1.1–1.4]

1.18

[1.1–1.4]

1.26

[1.1–1.4]

ns

 PTT (26–40 s)

45.65

[39.4–56.1]

51.10

[40.8–57.4]

41.1

[38.7–54.2]

ns

 Fibrinogen (1·6–4 g/l)

6.67

[4.7–7.7]

6.72

[5.0–7.8]

6.1

[4.6–7.9]

ns

 D-dimers (< 0·5 mg/l)

3.95

[2.6–5.9]

4.84

[3.5–7.2]

3.06

[2.3–3.9]

0.003

 max. D-dimers (< 0·5 mg/l)

8.25

[3.6–16.2]

11.57

[8.2–18.4]

3.98

[2.6–6.4]

< 0.001

 Procalcitonin (0·5 µg/l)

0.57

[0.2–2.5]

0.81

[0.4–4.7]

0.24

[0.2–1.3]

ns

 CRP (< 0·5 mg/l)

123.8

[84.3–216.5]

130

[86–273.7]

111

[79.3–185]

ns

 max. CRP (< 0·5 mg/l)

312.9

[208.3–343.9]

341.4

[261.1–370.7]

261.05

[175.3–312.9]

0.002

 IL-6 (< 7 ng/l)

103

[35·6–230]

88

[27.7–340]

153

[53.7–206.5]

ns

 max. IL-6 (< 7 ng/l)

558.6

[178.8–1792.3]

550

[174–2475]

567.2

[186.5–1196.5]

ns

 Ferritin (30–400 µg/l)

1636

[1067.8–4028.5]

1663

[1218.5–4655]

1567

[720–3662]

ns

 max. Ferritin (30–400 µg/l)

2523.2

[1536.7–6635.1]

2781.5

[1854.7–7996.2]

2028.4

[922.9–4893.4]

ns

 tPA (2–8 µg/l)

1

[0.9–5.5]

1

[0.9–3.6]

2

[0.9–9.9]

ns

 PAI-1 (7–43 ng/ml)

36

[17–70]

31

[12–61]

42.50

[25.3–87]

ns

 tPA/PAI-1

0.053

[0.02–0.18]

0.05

[0.02–0.14]

11

[0.03–0.24]

ns

 Antithrombin III (80–120%)

79

[58.5–96.5]

75.5

[56.8–84]

94

[66.5–110]

ns

 Factor VIII (50–150%)

258

[190.5–319.5]

260

[219.5–355]

222

[149.5–289.5]

ns

 Plasminogen (80–120%)

88

[72.8–114]

82

[72.8–109.8]

101

[70.8–129.8]

ns

ROTEM variables

 FIBTEM CT (s)

88.5

[78–97.8]

89

[78–102]

88

[75.5–96]

ns

 FIBTEM CFT (s)

68

[51–104]

64.5

[54–95.8]

71

[47–165]

ns

 FIBTEM MCF (mm)

34.5

[27.3–39.5]

35

[27–38]

34

[27–40]

ns

 EXTEM CT (s)

86

[69.5–99.8]

84

[69–96]

86

[70.5–107.5]

ns

 EXTEM CFT (s)

46.5

[40–60.5]

47

[40–61]

45

[40.5–56.5]

ns

 EXTEM MCF (mm)

75

[70.3–78]

75

[69–78]

76

[72.5–78.5]

ns

 INTEM CT (s)

208

[181.3–227.5]

215

[197–251]

189

[171.5–212]

0.005

 INTEM CFT (s)

50.5

[39.5–61.8]

56

[39–63]

45

[39.5–60.5]

ns

 INTEM MCF (mm)

74

[69–77]

74

[65–77]

73

[69.5–78]

ns

 HEPTEM CT (s)

188.5

[170.5–208.3]

193

[173–209]

173

[159–206]

ns

 HEPTEM CFT (s)

41

[35.5–56.5]

40

[34–60]

42

[37–51]

ns

 HEPTEM MCF (mm)

73

[67.5–75.3]

73

[66–76]

71

[71–75]

ns

 ML, EXTEM (%)

3

[1.3–5.8]

3

[0–5]

5

[3.5–8]

0.001

 ML, INTEM (%)

3

[1–6]

2

[0–3]

6

[2.5–6]

0.001