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Table 4 Host and viral mechanisms of SARS-CoV-2-pneumonia-associated pathogenesis

From: SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Propositions of host and viral mechanisms of SARS-CoV-2-associated pathogenesis

Direct viral induced pathology

Innate immune responses

Adaptive immune responses

- ACE2 impaired function

- Cytokine overproduction

- Impaired anti-inflammatory properties

- Endothelial dysfunction

- Neutrophilia

- Excessive cytokine production

- Denudation of the airways


- Amplification of local and systemic inflammation