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Table 4 Host and viral mechanisms of SARS-CoV-2-pneumonia-associated pathogenesis

From: SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Propositions of host and viral mechanisms of SARS-CoV-2-associated pathogenesis
Direct viral induced pathology Innate immune responses Adaptive immune responses
- ACE2 impaired function - Cytokine overproduction - Impaired anti-inflammatory properties
- Endothelial dysfunction - Neutrophilia - Excessive cytokine production
- Denudation of the airways   - Amplification of local and systemic inflammation