Table 4 Host and viral mechanisms of SARS-CoV-2-pneumonia-associated pathogenesis
From: SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review
Propositions of host and viral mechanisms of SARS-CoV-2-associated pathogenesis | ||
|---|---|---|
Direct viral induced pathology | Innate immune responses | Adaptive immune responses |
- ACE2 impaired function | - Cytokine overproduction | - Impaired anti-inflammatory properties |
- Endothelial dysfunction | - Neutrophilia | - Excessive cytokine production |
- Denudation of the airways | - Amplification of local and systemic inflammation | |