SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Table 2 Lung autopsy findings from COVID-19 patients

Lung pathology characteristic of COVID-19
Lung oedema [28, 29, 34]
Diffuse alveolar damage [28, 29, 34,35,36,37,38]
Multiple thrombi on the distal lumen of pulmonary vessels [28, 29, 35, 38]
T cells around pulmonary vessels, bronchioles and within interstitium (mainly CD4 and CD8) [28, 29, 31, 34]
Intussusceptive angiogenesis predominating over sprouting angiogenesis [29]
Pulmonary endothelial cells: twice as many angiotensin-converting enzyme 2 when compared to pneumocytes [29]
Pulmonary endothelial cells: disruption of intercellular junctions, swelling, shrinking of capillary lumen, loss of contact with the basal membrane [29, 34]

ISSN: 1364-8535