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Fig. 1 | Critical Care

Fig. 1

From: SARS-CoV-2 pneumonia—receptor binding and lung immunopathology: a narrative review

Fig. 1

Permission was granted by Walls et al. (©Elsevier [21]) to reuse this figure

Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) binds with high affinity to human angiotensin-converting enzyme 2 (ACE2) and uses it as an entry receptor to invade target cells. Cryo-Electron Microscopy structures of the SARS-CoV-2 spike glycoprotein in two distinct conformations, along with inhibition of spike-mediated entry by SARS-CoV (the coronavirus that emerged in the Guangdong province of China in 2002) polyclonal antibodies, provide a blueprint for the design of vaccines and therapeutics;

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