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Table 3 Single predictor models of Cox proportional hazard analysis

From: Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS

Variables

HR

95% (CI)

p

Age (year)

1.04

1.003–1.078

0.035

Sex (female)

0.006

0.000–0.216

0.006

Fever (days)

1.001

0.912–1.098

0.98

Pulmonary disease

1.998

0.906–4.408

0.086

Coronary artery disease

0.556

0,166–1.858

0.340

Hypertension

1,767

0.706–4.429

0.224

Diabetes

1.525

0.571–4.072

0.40

Smokers

3.050

1.313–7.086

0.10

Obesity

2.252

1.027–4.936

0.044

Risk factors

–

–

0.025

0

Ref

–

–

1

6.608

0.853–51

0.07

2

5.126

0.617–42.6

0.13

3

15.518

1.861–129

0.011

4

46.105

2.772–766

0.008

Nasal oxygen

0.019

0.001–0.512

0.018

Noninvasive ventilation

0.031

0.001–1.386

0.073

Intubation

223,89

4.81–10,415

0.006

PaO2/FiO2 ratio (mmHg)

0.986

0.981–0.992

0.001

Heparin

0.274

0.037–2.039

0.206

Antivirals

5.935

1.398–25.186

0.016

Hydroxycloroquine

1.195

0.477–2.995

0.704

Monoclonal antibody

3.301

1.481–7.356

0.003

Corticosteroids

1.308

0.521–3.279

0.568

Creatinine (mg/mL)

1.236

1.067–1.432

0.005

Troponine (pg/l)

1.000

1.000–1.000

0.003

D-dimer (ng/ml)

1.000

1.000–1.001

 < 0.001

C-reactive protein (mg/dl)

1.014

1.004–1.024

0.006

Procalcitonin (ng/ml)

1.108

0.975–1.259

0.115

NT-proBNP (pg/ml)

1.000

1.000–1.000

 < 0.001

APTT (sec)

0.997

0.982–1.012

0.687

Interleukine-6 (ng/ml)

1.010

1.007–1.013

 < 0.001

Heart rate (bpm)

1.031

1.006–1.058

0.016

Systolic blood pressure (mmHg)

0.976

0.949–1.003

0.076

Diastolic blood pressure (mmHg)

0.912

0.868–0.958

 < 0.001

LVEDd (mm)

1.031

0.948–1.121

0.473

LVESd (mm)

1.039

0.99–1.091

0.123

LAD (mm)

1.066

0.995–1.143

0.068

LVEF (%)

0.972

0.934–1.011

0.151

Severe MR

0.526

0.071–3.887

0.529

Severe AR

0.049

0–201,330

0.697

Severe TR

2.671

0.798–8.95

0.111

TAPSE (mm)

0.796

0.727–0.871

 < 0.001

PASP (mmHg)

1.085

1.054–1.118

 < 0.001

TAPSE/PASP (mm/mmHg)

0.013

0.002–0.069

 < 0.001

IVC (mm)

1.335

1.201–1.483

 < 0.001

IVC respiratory changes

1.591

0.702–3.606

0.226

Pericardial effusion

1.693

0.580–4.940

0.335

Pleural effusion

0.868

0.204–3.689

0.848

Right phenotype

4.232

1.505–11.902

0.006

  1. APTT partial thromboplastin time, NT-proBNP N-terminal prohormone of brain natriuretic peptide, LVEDD left ventricle end-diastolic diameter, LVESD left ventricle end-systolic diameter, LAD left atrium diameter, LVEF left ventricle ejection fraction, MVD mitral valve disease moderate-to-severe, AoVD aortic valve disease moderate-to-severe, TR tricuspid regurgitation, TAPSE tricuspid annulus plane systolic excursion, PASP pulmonary artery systolic pressure, IVC inferior vena cava