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Table 3 Single predictor models of Cox proportional hazard analysis

From: Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS

Variables HR 95% (CI) p
Age (year) 1.04 1.003–1.078 0.035
Sex (female) 0.006 0.000–0.216 0.006
Fever (days) 1.001 0.912–1.098 0.98
Pulmonary disease 1.998 0.906–4.408 0.086
Coronary artery disease 0.556 0,166–1.858 0.340
Hypertension 1,767 0.706–4.429 0.224
Diabetes 1.525 0.571–4.072 0.40
Smokers 3.050 1.313–7.086 0.10
Obesity 2.252 1.027–4.936 0.044
Risk factors 0.025
0 Ref
1 6.608 0.853–51 0.07
2 5.126 0.617–42.6 0.13
3 15.518 1.861–129 0.011
4 46.105 2.772–766 0.008
Nasal oxygen 0.019 0.001–0.512 0.018
Noninvasive ventilation 0.031 0.001–1.386 0.073
Intubation 223,89 4.81–10,415 0.006
PaO2/FiO2 ratio (mmHg) 0.986 0.981–0.992 0.001
Heparin 0.274 0.037–2.039 0.206
Antivirals 5.935 1.398–25.186 0.016
Hydroxycloroquine 1.195 0.477–2.995 0.704
Monoclonal antibody 3.301 1.481–7.356 0.003
Corticosteroids 1.308 0.521–3.279 0.568
Creatinine (mg/mL) 1.236 1.067–1.432 0.005
Troponine (pg/l) 1.000 1.000–1.000 0.003
D-dimer (ng/ml) 1.000 1.000–1.001  < 0.001
C-reactive protein (mg/dl) 1.014 1.004–1.024 0.006
Procalcitonin (ng/ml) 1.108 0.975–1.259 0.115
NT-proBNP (pg/ml) 1.000 1.000–1.000  < 0.001
APTT (sec) 0.997 0.982–1.012 0.687
Interleukine-6 (ng/ml) 1.010 1.007–1.013  < 0.001
Heart rate (bpm) 1.031 1.006–1.058 0.016
Systolic blood pressure (mmHg) 0.976 0.949–1.003 0.076
Diastolic blood pressure (mmHg) 0.912 0.868–0.958  < 0.001
LVEDd (mm) 1.031 0.948–1.121 0.473
LVESd (mm) 1.039 0.99–1.091 0.123
LAD (mm) 1.066 0.995–1.143 0.068
LVEF (%) 0.972 0.934–1.011 0.151
Severe MR 0.526 0.071–3.887 0.529
Severe AR 0.049 0–201,330 0.697
Severe TR 2.671 0.798–8.95 0.111
TAPSE (mm) 0.796 0.727–0.871  < 0.001
PASP (mmHg) 1.085 1.054–1.118  < 0.001
TAPSE/PASP (mm/mmHg) 0.013 0.002–0.069  < 0.001
IVC (mm) 1.335 1.201–1.483  < 0.001
IVC respiratory changes 1.591 0.702–3.606 0.226
Pericardial effusion 1.693 0.580–4.940 0.335
Pleural effusion 0.868 0.204–3.689 0.848
Right phenotype 4.232 1.505–11.902 0.006
  1. APTT partial thromboplastin time, NT-proBNP N-terminal prohormone of brain natriuretic peptide, LVEDD left ventricle end-diastolic diameter, LVESD left ventricle end-systolic diameter, LAD left atrium diameter, LVEF left ventricle ejection fraction, MVD mitral valve disease moderate-to-severe, AoVD aortic valve disease moderate-to-severe, TR tricuspid regurgitation, TAPSE tricuspid annulus plane systolic excursion, PASP pulmonary artery systolic pressure, IVC inferior vena cava