From: YKL-40 as a new promising prognostic marker of severity in COVID infection
Variables | ICU, No (n = 72) | ICU, Yes (n = 31) | p value |
---|---|---|---|
Age (year) | 71 (58–82) | 65 (59–69) | < 0.05 |
Gender M/F | 44/28 | 22/9 | NS |
Height (cm) | 169 (162–176) | 175 (169–180) | < 0.05 |
Weight (kg) | 71 (63–84) | 96 (80–105) | < 0.0001 |
BMI (kg/m2) | 25 (22–29) | 31 (27–34) | < 0.0001 |
Abnormal lung lesions (%) | 20 (10–35) | 40 (30–50) | < 0.001 |
SpO2 (%) | 93 (89–96) | 88 (75–90) | < 0.0001 |
Death, No/Yes (%) | 92.8/7.2 | 89.3/10.7 | NS |
Shock or organ failure, No/Yes (%) | 91.3/8.7 | 26.7/73.3 | < 0.0001 |
Cardiopathy, No/Yes (%) | 85.5/14.5 | 75/25 | NS |
ARF, No/Yes (%) | 79.7/20.3 | 40/60 | < 0.001 |
CRF, No/Yes (%) | 85.5/14.5 | 96.7/3.3 | NS |
Diabetes, No/Yes (%) | 85.5/14.5 | 62.1/37.9 | < 0.05 |
Red blood cells (× 10e6/µl) | 4.29 ± 0.79 | 4.48 ± 0.85 | NS |
Hematocrit (%) | 38 ± 7 | 39 ± 7 | NS |
Hemoglobin (g/dl) | 13 ± 2 | 14 ± 2 | NS |
Globular volume (fl) | 89 ± 8 | 89 ± 7 | NS |
Reticulocytes (%) | 0.97 (0.72–1.15) | 1 (0.57–1.04) | NS |
Reticulocytes (× 103/µl) | 39 (29–50) | 39 (24–51) | NS |
Leucocytes (× 10e3/µl) | 6.15 (4.63–8.03) | 7.87 (4.91–13.54) | < 0.05 |
Blood neutrophils (%) | 73 ± 12 | 78 ± 17 | < 0.05 |
Blood lymphocytes (%) | 15 (10–24) | 10 (5–20) | < 0.05 |
Blood monocytes (%) | 0.2 (0–0.9) | 0 (0–0.1) | < 0.01 |
Blood eosinophils (%) | 7.73 ± 4.36 | 5.63 ± 3.32 | NS |
Blood basophils (%) | 0.2 (0.2–0.4) | 0.2 (0.1–0.3) | NS |
Blood neutrophils (103/µl) | 4.54 (3.07–6.4) | 6.96 (3.5–11.73) | < 0.05 |
Blood lymphocytes (103/µl) | 0.96 (0.69–1.27) | 0.73 (0.59–1.12) | NS |
Blood monocytes (103/µl) | 0.42 (0.25–0.6) | 0.37 (0.27–0.6) | NS |
Blood eosinophils (103/µl) | 0.01 (0–0.05) | 0 (0–0.01) | < 0.05 |
Blood basophils (103/µl) | 0.01 (0.01–0.02) | 0.02 (0.01–0.03) | NS |
Platelets (103/µl) | 195 (157–266) | 189 (155–252) | NS |
Quick time (%) | 83 ± 22 | 83 ± 13 | NS |
Quick time (s) | 13 (12–13) | 13 (12–13) | NS |
Fibrinogen (g/l) | 5.24 ± 1.61 | 6.06 ± 2.01 | NS |
D-dimers (µg/L) | 876 (517–1787) | 1483 (586–2422) | NS |
Erythrocytes sedimentation rate (mm/h) | 123 (123–123) | 48 (48–48) | NS |
Iron (µmol/l) | 4.27 (2.95–7.36) | 4.61 (3.35–7.06) | NS |
Ferritin (µg/l) | 827 (499–1677) | 1861 (889–4117) | < 0.05 |
Osmolality (mosm/kg) | 290 ± 15 | 286 ± 11 | NS |
Sodium (mmol/l) | 139 ± 5 | 136 ± 4 | < 0.05 |
Chlorides (mmol/l) | 102 ± 6 | 100 ± 5 | NS |
Potassium (mmol/L) | 4.04 ± 0.44 | 4.16 ± 0.62 | NS |
Calcium (mmol/l) | 2.23 ± 0.18 | 2.14 ± 0.21 | NS |
Phosphates (mg/l) | 0.99 ± 0.2 | 1.15 ± 0.34 | NS |
Bicarbonates (mmol/l) | 24 (21–26) | 23 (19–26) | NS |
Creatinine (mg/dl) | 0.93 (0.8–1.31) | 1.25 (0.88–1.6) | 0.05 |
Urea (mg/dL) | 41 (31–68) | 53 (40–84) | < 0.05 |
GFR (MDRD) (ml/min/1.73m2) | 71 ± 33 | 60 ± 30 | NS |
Total protein (g/l) | 66 ± 8 | 66 ± 11 | NS |
Albumin (g/l) | 37 ± 5 | 36 ± 4 | NS |
Uric acid (mg/dl) | 61 ± 25 | 63 ± 25 | NS |
CRP (mg/l) | 58 (26–144) | 166 (105–265) | < 0.0001 |
Total bilirubin (mg/dl) | 0.62 (0.44–0.82) | 0.79 (0.53–1.02) | < 0.05 |
Conjugated bilirubin (mg/dl) | 0.25 (0.18–0.34) | 0.33 (0.25–0.5) | < 0.05 |
Alkaline phosphatase (U/l) | 75 (59–90) | 70 (57–95) | NS |
GGT (U/l) | 52 (30–111) | 64 (29–133) | NS |
ASAT (U/L) | 35 (24–53) | 60 (35–80) | < 0.001 |
ALAT (U/L) | 27 (17–46) | 36 (26–56) | < 0.05 |
LDH (U/l) | 310 (244–441) | 503 (411–703) | < 0.00001 |
Lipase (U/l) | 32 (19–50) | 38 (25–53) | NS |
Creatine kinase (U/l) | 136 (59–266) | 229 (101–426) | 0.07 |
YKL-40 (ng/ml) | 186 (84–384) | 241 (172–827) | < 0.05 |