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Table 1 Comparison between COVID-19 patients admitted to intensive care or not

From: YKL-40 as a new promising prognostic marker of severity in COVID infection

Variables

ICU, No (n = 72)

ICU, Yes (n = 31)

p value

Age (year)

71 (58–82)

65 (59–69)

< 0.05

Gender M/F

44/28

22/9

NS

Height (cm)

169 (162–176)

175 (169–180)

< 0.05

Weight (kg)

71 (63–84)

96 (80–105)

< 0.0001

BMI (kg/m2)

25 (22–29)

31 (27–34)

< 0.0001

Abnormal lung lesions (%)

20 (10–35)

40 (30–50)

< 0.001

SpO2 (%)

93 (89–96)

88 (75–90)

< 0.0001

Death, No/Yes (%)

92.8/7.2

89.3/10.7

NS

Shock or organ failure, No/Yes (%)

91.3/8.7

26.7/73.3

< 0.0001

Cardiopathy, No/Yes (%)

85.5/14.5

75/25

NS

ARF, No/Yes (%)

79.7/20.3

40/60

< 0.001

CRF, No/Yes (%)

85.5/14.5

96.7/3.3

NS

Diabetes, No/Yes (%)

85.5/14.5

62.1/37.9

< 0.05

Red blood cells (× 10e6/µl)

4.29 ± 0.79

4.48 ± 0.85

NS

Hematocrit (%)

38 ± 7

39 ± 7

NS

Hemoglobin (g/dl)

13 ± 2

14 ± 2

NS

Globular volume (fl)

89 ± 8

89 ± 7

NS

Reticulocytes (%)

0.97 (0.72–1.15)

1 (0.57–1.04)

NS

Reticulocytes (× 103/µl)

39 (29–50)

39 (24–51)

NS

Leucocytes (× 10e3/µl)

6.15 (4.63–8.03)

7.87 (4.91–13.54)

< 0.05

Blood neutrophils (%)

73 ± 12

78 ± 17

< 0.05

Blood lymphocytes (%)

15 (10–24)

10 (5–20)

< 0.05

Blood monocytes (%)

0.2 (0–0.9)

0 (0–0.1)

< 0.01

Blood eosinophils (%)

7.73 ± 4.36

5.63 ± 3.32

NS

Blood basophils (%)

0.2 (0.2–0.4)

0.2 (0.1–0.3)

NS

Blood neutrophils (103/µl)

4.54 (3.07–6.4)

6.96 (3.5–11.73)

< 0.05

Blood lymphocytes (103/µl)

0.96 (0.69–1.27)

0.73 (0.59–1.12)

NS

Blood monocytes (103/µl)

0.42 (0.25–0.6)

0.37 (0.27–0.6)

NS

Blood eosinophils (103/µl)

0.01 (0–0.05)

0 (0–0.01)

< 0.05

Blood basophils (103/µl)

0.01 (0.01–0.02)

0.02 (0.01–0.03)

NS

Platelets (103/µl)

195 (157–266)

189 (155–252)

NS

Quick time (%)

83 ± 22

83 ± 13

NS

Quick time (s)

13 (12–13)

13 (12–13)

NS

Fibrinogen (g/l)

5.24 ± 1.61

6.06 ± 2.01

NS

D-dimers (µg/L)

876 (517–1787)

1483 (586–2422)

NS

Erythrocytes sedimentation rate (mm/h)

123 (123–123)

48 (48–48)

NS

Iron (µmol/l)

4.27 (2.95–7.36)

4.61 (3.35–7.06)

NS

Ferritin (µg/l)

827 (499–1677)

1861 (889–4117)

< 0.05

Osmolality (mosm/kg)

290 ± 15

286 ± 11

NS

Sodium (mmol/l)

139 ± 5

136 ± 4

< 0.05

Chlorides (mmol/l)

102 ± 6

100 ± 5

NS

Potassium (mmol/L)

4.04 ± 0.44

4.16 ± 0.62

NS

Calcium (mmol/l)

2.23 ± 0.18

2.14 ± 0.21

NS

Phosphates (mg/l)

0.99 ± 0.2

1.15 ± 0.34

NS

Bicarbonates (mmol/l)

24 (21–26)

23 (19–26)

NS

Creatinine (mg/dl)

0.93 (0.8–1.31)

1.25 (0.88–1.6)

0.05

Urea (mg/dL)

41 (31–68)

53 (40–84)

< 0.05

GFR (MDRD) (ml/min/1.73m2)

71 ± 33

60 ± 30

NS

Total protein (g/l)

66 ± 8

66 ± 11

NS

Albumin (g/l)

37 ± 5

36 ± 4

NS

Uric acid (mg/dl)

61 ± 25

63 ± 25

NS

CRP (mg/l)

58 (26–144)

166 (105–265)

< 0.0001

Total bilirubin (mg/dl)

0.62 (0.44–0.82)

0.79 (0.53–1.02)

< 0.05

Conjugated bilirubin (mg/dl)

0.25 (0.18–0.34)

0.33 (0.25–0.5)

< 0.05

Alkaline phosphatase (U/l)

75 (59–90)

70 (57–95)

NS

GGT (U/l)

52 (30–111)

64 (29–133)

NS

ASAT (U/L)

35 (24–53)

60 (35–80)

< 0.001

ALAT (U/L)

27 (17–46)

36 (26–56)

< 0.05

LDH (U/l)

310 (244–441)

503 (411–703)

< 0.00001

Lipase (U/l)

32 (19–50)

38 (25–53)

NS

Creatine kinase (U/l)

136 (59–266)

229 (101–426)

0.07

YKL-40 (ng/ml)

186 (84–384)

241 (172–827)

< 0.05

  1. When the data follow a normal distribution, the results are expressed as mean ± standard deviation, and otherwise, they are expressed as the median (IQR)
  2. M, male; F, female; NS, nonsignificant