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Table 2 Outcomes by initial dosing strategy of thromboprophylaxis

From: Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients

 

Total (n = 152)

Initial dosing strategy of thromboprophylaxis

p-valued

Low dosea (n = 67)

Medium doseb (n = 48)

High dose c (n = 37)

Primary outcome

 28-day mortality, No. (%)

43 (28.3)

26 (38.8)

12 (25.0)

5 (13.5)

0.02

Secondary outcomes

 ICU-free days alive during 28 days from ICU-admission, days

9 (0–21)

0 (0–20)

11 (0–19)

18 (0–26)

0.07

 Thromboembolic events < 28 days, No. (%)

22 (14.5)

12 (17.9)

9 (18.8)

1 (2.7)

0.04

  Pulmonary embolism, No. (%)

17 (11.2)

10 (14.9)

6 (12.5)

1 (2.7)

0.15

  Deep vein thrombosis, No. (%)

4 (2.6)

1 (1.5)

3 (6.3)

0 (0.0)

0.21

  Ischemic stroke, No. (%)

4 (2.7)

4 (6.0)

0 (0.0)

0 (0.0)

0.16

  Other thrombotic event, No. (%)

3 (2.0)

2 (3.0)

1 (2.1)

0 (0.0)

0.79

  Time to event, days

8 (6–17)

8 (6–20)

8 (6–10)

11 (11–11)

0.61

 Bleeding events < 28 days, No. (%)

16 (10.5)

8 (11.9)

7 (14.6)

1 (2.7)

0.16

  Cerebral parenchymal bleeding, No. (%)

2 (1.3)

2 (3.0)

0 (0.0)

0 (0.0)

0.50

  WHO bleeding assessment score

   Grade I—minor, No. (%)

8 (5.3)

3 (4.5)

4 (8.3)

1 (2.7)

0.58

   Grade II—moderate, No. (%)

3 (2.0)

2 (3.0)

1 (2.1)

0 (0.0)

0.79

   Grade III—major, No. (%)

2 (1.3)

1 (1.5)

1 (2.1)

0 (0.0)

0.99

   Grade IV—severe, No. (%)

3 (2.0)

2 (3.0)

1 (2.1)

0 (0.0)

0.79

  Time to bleeding event, days

13 (8–18)

16 (6–20)

11 (10–20)

1 (1–1)

0.36

Lab characteristics

 Fibrin-D-dimer, mg/L FEU, highest

3.2 (1.2–9.9)

6.4 (2.0–14.6)

2.8 (1.2–9.4)

1.7 (0.7–3.3)

0.002

 CRP, mg/L, highest

282 (183–381)

335 (200–423)

290 (201–385)

229 (162–319)

0.01

 Hemoglobin, g/L, lowest

98 (85–113)

94 (80–104)

102 (94–116)

107 (95–118)

0.01

 Creatinine, µmol/L, highest

82 (64–158)

100 (78–236)

78 (55–139)

66 (49–74)

 < 0.001

 Platelet count, 109/L, lowest

239 (180–322)

203 (164–282)

257 (197–290)

314 (218–370)

0.003

 INR, highest

1.1 (1.0–1.2)

1.1 (1.0–1.2)

1.1 (1.0–1.2)

1.0 (1.0–1.1)

0.18

  1. Primary and secondary outcomes during the first 28 days among 152 patients admitted to the intensive care unit due to COVID-19 at Södersjukhuset, Stockholm, March 6 to April 30, 2020, by initial dosing strategy with tinzaparin/dalteparin as thromboprophylaxis
  2. Values are medians (interquartile range) unless otherwise indicated. p-values for differences across exposure categories were obtained using Fisher´s exact test for categorical, and Kruskal Wallis for continuous, data. CRP, C-reactive protein; ICU, intensive care unit; OD, once a day; IQR, interquartile range; WHO, World Health Organization
  3. aTinzaparin, 2500–4500 IU OD; or dalteparin, 2500–5000 IU OD
  4. bTinzaparin, > 4500 IU OD to < 175 IU/kg of body weight OD; or dalteparin, > 5000 IU OD to < 200 IU/kg of body weight OD
  5. cTinzaparin, ≥ 175 IU/kg of body weight OD; or dalteparin, ≥ 200 IU/kg of body weight OD
  6. dp values for differences across exposure categories were obtained using Fisher’s exact test for categorical and Kruskal–Wallis test for continuous data
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