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Fig. 7 | Critical Care

Fig. 7

From: Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Fig. 7

Xenon treatment enhances early astrocyte activation. a Typical immunostaining showing GFAP (red) staining from sham, TBI control and TBI xenon animals in right hippocampal CA1 region. The scale bar is 50 μm and applies to all images. b Quantification of GFAP-positive area in sham (white bars), TBI control (blue bars) and TBI xenon (red bars) in i motor/medial parietal association cortex (M1/MPtA) & contusional cortex, ii somatosensory cortex (S1BF), iii retrosplenial cortex (RSC) iv hypothalamus, v amygdala, vi hippocampal CA1, vii CA2, viii CA3, ix dentate gyrus (DG) and x corpus callosum. The lines are medians, boxes represent interquartile interval and whiskers are range. n = 6 sham (white boxes); n = 6, TBI control (blue boxes); n = 5 TBI xenon (red boxes) * p < 0.05, ** p < 0.01, compared to sham group or control TBI group as indicated by brackets, Kruskal Wallis test with Benjamini Yekutieli correction

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Critical Care

ISSN: 1364-8535