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Fig. 3 | Critical Care

Fig. 3

From: Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Fig. 3

a Typical immunostaining showing NeuN (yellow) and DAPI (red) staining from sham, TBI control and TBI xenon animals in i right somatosensory cortex layers 2/3, ii left motor/association cortex layers 2/3 and iii right retrosplenial cortex layers 2/3/4. Live neurons show a strong NeuN staining combined with DAPI. The scale bar is 20 μm and applies to all images. b Xenon prevents neuronal loss in specific cortical regions 24 h after TBI. Quantification of neuronal cell density of cortical layers from sham (white bars), TBI control (blue bars) and TBI xenon (red bars) in i left motor/medial parietal association cortex (M1/MPtA), ii left somatosensory cortex (S1BF), iii right somatosensory cortex (S1BF), iv left retrosplenial cortex (RSC), v right retrosplenial cortex (RSC). The lines are medians, boxes represent interquartile interval and whiskers are range. * p < 0.05; ** p < 0.01; *** p < 0.001, compared to sham group or control TBI group as indicated by brackets, Kruskal Wallis test with Benjamini Yekutieli correction. n = 6 sham (white boxes) 24 h, n = 6, TBI control 24 h (blue boxes); n = 5 TBI xenon 24 h (red boxes)

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Critical Care

ISSN: 1364-8535