Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study

Table 1 Data comparisons for responders and non-responders at baseline and after 15 to 30 min of nitric oxide (iNO) inhalation

Variables	Non-responder (n = 12)	Responder (n = 22)	P value
PaCO₂ (mmHg)
Baseline	49 [36–56]	48 [42–60]	0.363
After iNO	47 [42–60]	47 [38–52]	0.444
P value before/after iNO	0.581	0.067
PaO₂ (mmHg)
Baseline	134 [80–160]	65 [58–86]	< 0.0001
After iNO	72 [68–108]	92 [73–131]	0.110
P value before/after iNO	< 0.009	< 0.0001
PaO₂/FiO₂
Baseline	134 [83–173]	70 [63–100]	< 0.0001
After iNO	125 [92–144]	144 [107–175]	0.068
P value before/after iNO	0.005	< 0.0001
FiO₂
Baseline	0.8 [0.7–0.9]	0.95 [0.7–1.0]	0.168
After iNO	0.75 [0.65–0.90]	0.70 [0.6–0.8]	0.557
P value before/after iNO	0.399	0.002
PEEP (cmH₂0)
Baseline	12 [10–12]	12 [9–15]	0.790
After iNO	12 [10–13]	13 [9–15]	0.486
P value before/after iNO	1.000	0.337
Driving pressure (cm H₂0)
Baseline	15 [14–17]	16 [14–17]	0.209
After iNO	14 [13–16]	13 [13–16]	1.000
P value before/after iNO	0.221	0.098
RS compliance (ml cmH₂0⁻¹)
Baseline	30.0 [21.8–36.7]	26.6 [20.2–31.8]	0.534
After iNO	33.9 [24.7–37.0]	30.0 [22.1–33.4]	0.407
P value before/after iNO	0.345	0.073
ACP, n (%)	4 (33)	6 (27)	0.714
Prone positioning after iNO, n (%)	7 (58)	0 (0)	< 0.0001
CT scan features
GGO	10 (83)	20 (91)	0.602
Consolidation	6 (50)	14 (64)	0.487
ICU mortality, n (%)	5 (42)	8 (36)	1.000

Change over time within groups was determined by Wilcoxon signed rank test (P value before/after iNO) and between groups were determined by Mann–Whitney test (P value)
PEEP positive end expiratory pressure, ACP acute cor pulmonale, RS respiratory system, FiO₂ inspired fraction in oxygen, GGO ground glass opacities, GGO ground glass opacities, CT scan computerized tomography scanner, ICU intensive care unit

ISSN: 1364-8535