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Table 3 Adjusted outcome after high TIL versus low TIL treatment (propensity score matched model)

From: Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis

Main analysis Sensitivity analyses
High TIL treatment High TIL treatment after day 1 High TIL treatment excluding barbiturates
  Nr OR [95% CI] p Nr OR [95% CI] p Nr OR [95% CI] p
Unfavourable GOSE ≤ 4 280 1.4 [1.0–2.0] 0.068 250 1.5 [1.1–2.2] 0.023 114 2.5 [1.4–4.7] 0.004
  1. This table describes the differences in outcome after receiving high Therapy Intensity Level (TIL) treatment versus low TIL treatment. Overall high TIL was defined as any high intensity treatment (decompressive craniectomy excluding day 1, barbiturates, intensive hypothermia, intensive hyperventilation) during ICU stay. The primary outcome is the GOSE after 6 months. We used a multivariate propensity score matched model with correction for centre effects (random intercept). Nearest neighbour matching was used to select patients with the similar propensity scores and different treatment status. Covariates used for matching were IMPACT variables and ‘ISS without head injury ‘and in the final model we corrected for maximum ICP values prior to treatment. For the sensitivity analyses, we only selected patient with high TIL treatments after day 1 or excluded patients receiving barbiturates
  2. CI: confidence interval, GOSE: Glasgow Outcome Scale Extended, ICP: intracranial pressure, ICU: intensive care unit, Nr: number of matches, OR: odds ratio, TIL: therapy intensity level