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Table 2 Substance specific clearances (ml/min) (primary and secondary endpoints)

From: Myoglobin clearance with continuous veno-venous hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled trial

End-points Time after starting treatment n Control arm CVVHDF Intervention arm CVVHD-HCO Mean difference p value#
Myoglobin 1 h 66 3.7 [2.3, 4.7] 12.3 [10.1, 14.4] 5.5 (4.0–7.0) < 0.0005
6 h 65 3.4 [1.6, 3.9] 10 [8.3, 12.7]
12 h 62 2.3 [1.5, 4] 8.3 [6.7, 10.7]
24 h 57 1.9 [0.2, 3.1] 8.2 [6.8, 10.3]
48 h 48 2.1 [0.1, 5.5] 6.9 [5.1, 8.8]
Urea 1 h 66 28.7 [25.6, 33.2] 24.8 [20.9, 28.7] − 5.3 (− 8.4− (− 2.3)) 0.001
6 h 65 29.6 [25, 31.4] 25.1 [22.8, 28.3]
12 h 62 28.8 [25.2, 32.9] 26.1 [19.8, 28.8]
24 h 57 28.6 [25.8, 32.4] 26.7 [20.9, 29.7]
48 h 48 31 [26.2, 32.8] 23 [20.4, 30.9]
Creatinine 1 h 66 31.4 [27.6, 35.9] 28.5 [24.7, 34.1] 4.2 (0.8–7.6) 0.015
6 h 65 31.7 [27.2, 34.5] 29.5 [25.3, 34.9]
12 h 62 31.1 [27.8, 34.8] 29.5 [22.5, 33]
24 h 58 31.5 [28, 37.1] 30.4 [24.6, 35.9]
48 h 48 32,9 [27.5, 36.5] 25.7 [23.7, 34.7]
β2− Microglobulin 1 h 66 21.1 [18, 23.8] 24.5 [19.2, 28.1] 4.4 (2.2–6.6) < 0.0005
6 h 65 19 [17.1, 22.4] 24.1 [21,1, 26.6]
12 h 62 7.8 [4.5, 10.9] 22.7 [18.2, 24.5]
24 h 57 16.4 [15.5, 19.4] 22.1 [19.2, 25.8]
48 h 48 18 [15.5, 20.4] 21.4 [16.9, 23.7]
Interleukin− 6 1 h 66 0.2 [− 0.9, 1.2] 5 [2.4, 5.9] 1.4 (− 0.3–3.1) 0.107
6 h 65 0.3 [− 1, 2.5] 2.5 [1, 3.5]
12 h 62 1.2 [0, 3.7] 1.8 [0.6, 3.4]
24 h 57 − 0.6 [− 1.3, 1.5] 1.6 [0.4, 3]
48 h 48 0.7 [− 1.1, 4.2] 1.3 [0, 2.3]
Albumin 1 h 66 − 3.4 [− 4.2, − 1.1] − 1.2 [− 2.6, 0.3] − 1.1 (− 2.7–0.5) 0,170
6 h 65 − 2.1 [− 3.5, 0.3] − 1.4 [− 3, − 0.2]
12 h 62 − 1.4 [− 2.9, 1.7] − 1.7 [− 3.1, − 0.1]
24 h 57 − 2.3 [− 4.5, − 0.8] − 1.6 [− 3.2, − 07]
48 h 48 − 1.7 [− 5.7, 1.2] − 2.4 [− 5, − 0.8]
  1. Data presented as † median [25th, 75th quantile], ‡ Estimated difference of marginal means (95% confidence interval)
  2. ml/min milliliters per minute, CVVHDF continuous veno-venous hemodiafiltration, CVVHD-HCO continuous veno-venous hemodialysis using high cutoff filter
  3. #p value from comparison of marginal means