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Table 1 Patient characteristics and clinical parameters at intensive care unit admission and on alignment day

From: Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

  Anakinra (n = 21) Control (n = 39) p value
Sex, male 14 (67) 33 (85) 0.19
Age, years 63 [55–71] 67 [59–72] 0.42
Body mass index, kg/m2 27.7 [25.9–29.9] 26.8 [24.3–31.1] 0.50
APACHE II 15 [13–18] 16 [12–20] 0.46
Time from first COVID symptoms until ICU admission, days 13 [9–14] 10 [7–15] 0.33
Medical history    
 Cardiovascular insufficiency 4 (19) 10 (26) 0.75
 Hypertension 8 (38) 22 (56) 0.28
 Respiratory insufficiency 1 (5) 2 (5) 1
 Renal insufficiency 0 (0) 1 (3) 1
 Metastatic neoplasm 2 (10) 2 (5) 0.61
 Immunological insufficiency 0 (0) 1 (3) 1
 Chronic obstructive pulmonary disease 0 (0) 5 (13) 0.15
 Diabetes mellitus 7 (33) 7 (18) 0.21
 Hematologic malignancy 1 (5) 0 (0) 0.35
Clinical parameters on admission day    
 D-dimer, ng/mL 3380 [2028–18343] 2950 [1605–4610] 0.28
 Creatinine, μmol/L 84 [68–96] 82 [65–110] 0.70
 Alanine transaminase, U/L 47 [21–62] 39 [30–56] 0.95
 Aspartate transaminase, U/L 55 [35–76] 51 [39–63] 0.96
 Bilirubin, μmol/L 8 [6–13] 7 [5–14] 0.53
 Lactate dehydrogenase, U/L 380 [322–493] 406 [324–507] 0.92
 White blood cells, × 109/L 8.2 [7.0–12.0] 9.8 [6.0–11.4] 0.95
 Thrombocytes, × 109/L 247 [189–324] 244 [181–325] 0.61
 C-reactive protein, mg/L 254 [188–297] 198 [133–292] 0.22
 Procalcitonin, μg/L 0.66 [0.18–1.39] 0.86 [0.32–2.88] 0.44
 Ferritin, μg/L 1842 [1313–2767] 1439 [815–2396] 0.19
 Temperature, °C 38.4 [37.8–38.9] 38.6 [37.5–39.3] 0.56
 PaO2/FiO2 ratio, mmHg 138 [105–199] 139 [101–178] 0.94
 SOFA score 7 [4–7] 6 [5–8] 0.27
Clinical parameters on alignment day    
 D-dimer, ng/mL 4063 [2585–6285] 3918 [2349–5943] 0.70
 Creatinine, μmol/L 92 [76–106] 79 [58–148] 0.55
 Alanine transaminase, U/L 89 [55–119] 67 [49–114] 0.24
 Aspartate transaminase, U/L 96 [67–142] 64 [46–97] 0.009
 Bilirubin, μmol/L 6 [5–12] 5 [4–9] 0.18
 Lactate dehydrogenase, U/L 371 [317–450] 348 [256–406] 0.11
 White blood cells, × 109/L 12.4 [10.4–15.9] 13.5 [11.4–16.6] 0.49
 Thrombocytes, × 109/L 351 [314–494] 366 [263–453] 0.34
 C-reactive protein, mg/L 130 [90–237] 92 [59–170] 0.13
 Procalcitonin, μg/L 0.66 [0.39–1.88] 0.48 [0.23–0.78] 0.07
 Ferritin, μg/L 2365 [1272–3713] 1410 [713–1680] 0.001
 Temperature, °C 39.1 [38.3–40.0] 37.8 [37.0–38.3] 0.0002
 PaO2/FiO2, mmHg 188 [133–268] 157 [128–212] 0.18
 SOFA score 6 [4–8] 5 [4–7] 0.75
 APACHE II 12 [9–13] 10 [7–14] 0.41
 Time from first COVID symptoms until alignment day, days 22 [19–27] 21 [18–26] 0.62
  1. Data are presented as n (%) or median [IQR]. p values were calculated using Fisher’s exact tests and Mann–Whiney-U tests