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Table 1 Patient characteristics and clinical parameters at intensive care unit admission and on alignment day

From: Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

 

Anakinra (n = 21)

Control (n = 39)

p value

Sex, male

14 (67)

33 (85)

0.19

Age, years

63 [55–71]

67 [59–72]

0.42

Body mass index, kg/m2

27.7 [25.9–29.9]

26.8 [24.3–31.1]

0.50

APACHE II

15 [13–18]

16 [12–20]

0.46

Time from first COVID symptoms until ICU admission, days

13 [9–14]

10 [7–15]

0.33

Medical history

   

 Cardiovascular insufficiency

4 (19)

10 (26)

0.75

 Hypertension

8 (38)

22 (56)

0.28

 Respiratory insufficiency

1 (5)

2 (5)

1

 Renal insufficiency

0 (0)

1 (3)

1

 Metastatic neoplasm

2 (10)

2 (5)

0.61

 Immunological insufficiency

0 (0)

1 (3)

1

 Chronic obstructive pulmonary disease

0 (0)

5 (13)

0.15

 Diabetes mellitus

7 (33)

7 (18)

0.21

 Hematologic malignancy

1 (5)

0 (0)

0.35

Clinical parameters on admission day

   

 D-dimer, ng/mL

3380 [2028–18343]

2950 [1605–4610]

0.28

 Creatinine, μmol/L

84 [68–96]

82 [65–110]

0.70

 Alanine transaminase, U/L

47 [21–62]

39 [30–56]

0.95

 Aspartate transaminase, U/L

55 [35–76]

51 [39–63]

0.96

 Bilirubin, μmol/L

8 [6–13]

7 [5–14]

0.53

 Lactate dehydrogenase, U/L

380 [322–493]

406 [324–507]

0.92

 White blood cells, × 109/L

8.2 [7.0–12.0]

9.8 [6.0–11.4]

0.95

 Thrombocytes, × 109/L

247 [189–324]

244 [181–325]

0.61

 C-reactive protein, mg/L

254 [188–297]

198 [133–292]

0.22

 Procalcitonin, μg/L

0.66 [0.18–1.39]

0.86 [0.32–2.88]

0.44

 Ferritin, μg/L

1842 [1313–2767]

1439 [815–2396]

0.19

 Temperature, °C

38.4 [37.8–38.9]

38.6 [37.5–39.3]

0.56

 PaO2/FiO2 ratio, mmHg

138 [105–199]

139 [101–178]

0.94

 SOFA score

7 [4–7]

6 [5–8]

0.27

Clinical parameters on alignment day

   

 D-dimer, ng/mL

4063 [2585–6285]

3918 [2349–5943]

0.70

 Creatinine, μmol/L

92 [76–106]

79 [58–148]

0.55

 Alanine transaminase, U/L

89 [55–119]

67 [49–114]

0.24

 Aspartate transaminase, U/L

96 [67–142]

64 [46–97]

0.009

 Bilirubin, μmol/L

6 [5–12]

5 [4–9]

0.18

 Lactate dehydrogenase, U/L

371 [317–450]

348 [256–406]

0.11

 White blood cells, × 109/L

12.4 [10.4–15.9]

13.5 [11.4–16.6]

0.49

 Thrombocytes, × 109/L

351 [314–494]

366 [263–453]

0.34

 C-reactive protein, mg/L

130 [90–237]

92 [59–170]

0.13

 Procalcitonin, μg/L

0.66 [0.39–1.88]

0.48 [0.23–0.78]

0.07

 Ferritin, μg/L

2365 [1272–3713]

1410 [713–1680]

0.001

 Temperature, °C

39.1 [38.3–40.0]

37.8 [37.0–38.3]

0.0002

 PaO2/FiO2, mmHg

188 [133–268]

157 [128–212]

0.18

 SOFA score

6 [4–8]

5 [4–7]

0.75

 APACHE II

12 [9–13]

10 [7–14]

0.41

 Time from first COVID symptoms until alignment day, days

22 [19–27]

21 [18–26]

0.62

  1. Data are presented as n (%) or median [IQR]. p values were calculated using Fisher’s exact tests and Mann–Whiney-U tests