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Table 3 Odds ratios for bio-ADM from multivariable binary logistic regression analyses for different outcomes

From: Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness

Outcome ICU population Sepsis cohort
OR 95% CI p value OR 95% CI p value
30-day mortality 1.22 1.12–1.32 < 0.001 1.23 1.07–1.41 0.003
30-day mortality N/A N/A N/A 1.20 1.04–1.38 0.010
Cardiovascular SOFA\(\ge\) 3 1.33 1.23–1.42 < 0.001 1.33 1.17–1.50 < 0.001
CRRT use during ICU stay 2.28 2.01–2.59 < 0.001 1.97 1.64–2.36 < 0.001
Sepsis 1.91 1.76–2.08 < 0.001 N/A N/A N/A
Sepsis* 1.78 1.64–1.94 < 0.001 N/A N/A N/A
Septic shock 1.95 1.76–2.16 < 0.001 1.45 1.28–1.65 < 0.001
Septic shock* 1.78 1.60–1.98 < 0.001 1.35 1.19–1.54 < 0.001
  1. The odds ratio for bio-ADM was calculated on a base 2 logarithmic scale. Age was included as a covariate in all regressions not including simplified acute physiology score III (SAPS3), as this is already an integral part of SAPS3. An additional covariate for the model was lactate, and for the * models, the SAPS3 was included. If the Hosmer–Lemeshow test was \(p<\) 0.05, the model was marked . ICU: intensive care unit; OR: odds ratio; CI: confidence interval; SOFA: Sequential Organ Failure Assessment; CRRT: continuous renal replacement therapy; N/A: not applicable