Table 3 Secondary outcomes
From: Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure
ALL (n = 218) | High-dose group (n = 117) | Low-dose group (n = 101) | P value | |
|---|---|---|---|---|
Severe bleeding events, n (%) | 37 (17.0) | 23 (19.7) | 14 (13.9) | 0.256 |
Gastrointestinal / intrabdominal | 12 (5.5) | 5 (4.3) | 7 (6.9) | |
Intracranial | 7 (3.2) | 7 (6.0) | 0 | |
Intrathoracic | 16 (7.3) | 10 (8.5) | 6 (5.9) | |
Cannula site | 2 (0.9) | 1 (0.9) | 1 (1.0) | |
Ear-nose-throat | 1 (0.5) | 1 (0.8) | 0 | |
RBC transfusions | 7 (3–13) | 6 (2–10) | 8 (6–19) | < 0.001 |
Platelet transfusions | 1 (0–5) | 0 (0–1) | 4 (0–10) | < 0.001 |
Thromboembolic events, n (%) | 27 (12.4) | 8 (6.8) | 19 (19) | 0.007 |
Intraabdominal embolism / thrombosis | 5 (2.3) | 3 (2.5) | 2 (2.0) | |
Venous thrombosis | 12 (5.5) | 4 (3.4) | 7 (6.9) | |
Pulmonary embolism | 3 (1.8) | 1 (0.9) | 2 (2.0) | |
Peripheral arterial embolism | 2 (0.9) | 0 | 2 (2.0) | |
ECMO filter embolism | 3 (1.8) | 0 | 3 (3.0) | |
ECMO cannula thrombosis | 1 (0.5) | 0 | 1 (1.0) | |
Ischemic stroke | 2 (0.9) | 0 | 2 (2.0) | |
Heparin-induced thrombocytopenia, n (%) | 3 (1.4) | 1 (0.9) | 2 (2.0) | |
30-day ICU mortality | 70 (32.1) | 39 (33.3) | 31 (30.7) | 0.110 |
Overall ICU mortality | 91 (41.7) | 47 (40.2) | 44 (43.6) | 0.612 |