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Table 1 Mean sieving coefficient and daily loss of amino acids, vitamins and trace elements

From: Clearance of micronutrients during continuous renal replacement therapy

Nutrient

Molecular weight [g/mol]

Mean SCa ± SE

95% CI

Daily lossb [mg]

Standardized daily lossc [mg]

Alanine

89.1

1.02 ± 0.03

0.95–1.09

1102.3 ± 98.4

603.7 ± 37.2

Arginine

174.2

0.99 ± 0.04

0.91–1.07

427.9 ± 42.4

237.6 ± 16.3

Aspartic acid

133.1

0.82 ± 0.07

0.67–0.97

32.9 ± 2.3

20.3 ± 1.9

Citrulline

175.2

0.93 ± 0.05

0.82–1.03

756.0 ± 45.3*

439.4 ± 24.9*

Glutamic acid

147.1

0.53 ± 0.03

0.47–0.60

208.71 ± 17.3

118.4 ± 7.4

Glutamine

146.2

0.96 ± 0.03

0.90–1.01

2525.9 ± 172.8

1397.3 ± 68.1

Glycine

75.1

0.89 ± 0.03

0.82–0.96

558.1 ± 39.8

317.4 ± 20.1

Histidine

155.2

0.83 ± 0.02

0.78–0.87

387.9 ± 27.7

216.4 ± 12.1

Hydroxyproline

131.1

6.63 ± 0.83

4.94–8.31

224.7 ± 28.6

131.3 ± 18.5

Isoleucine

131.2

0.94 ± 0.02

0.89–0.99

373.9 ± 35.2

206.9 ± 13.1

Leucine

131.2

0.81 ± 0.02

0.76–0.86

592.5 ± 57.8

330.2 ± 21.9

Lysine

146.2

0.88 ± 0.03

0.83–0.94

968.1 ± 90.3

535.4 ± 38.6

Methionine

149.2

0.90 ± 0.03

0.83–0.97

182.5 ± 19.4

100.0 ± 8.1

Ornithine

132.2

0.70 ± 0.02

0.66–0.74

291.1 ± 28.5

161.4 ± 11.2

Phenylalanine

165.2

0.91 ± 0.03

0.85–0.96

626.1 ± 57.8

349.6 ± 25.1

Proline

115.1

0.75 ± 0.02

0.71–0.79

558.4 ± 47.7

308.0 ± 21.4

Serine

105.1

0.96 ± 0.04

0.88–1.04

339.3 ± 24.4

196.8 ± 9.9

Taurine

125.2

0.77 ± 0.08

0.62–0.93

124.4 ± 2.2

71.1 ± 12

Threonine

119.1

1.00 ± 0.03

0.95–1.06

496.8 ± 43.7

276.4 ± 20.0

Tryptophan

204.2

0.55 ± 0.03

0.49–0.61

128.1 ± 11.9

72.8 ± 4.9

Tyrosine

181.2

0.96 ± 0.02

0.91–1.01

554.5 ± 51.9

307.3 ± 20.9

Valine

117.1

0.88 ± 0.02

0.84–0.93

895.5 ± 81.7

499.4 ± 29.6

Carnitine

161.2

0.92 ± 0.04

0.83–1.01

1698.0 ± 134.7*

981.9 ± 75.8*

Vitamin B1

265.4

UD

UD

UD

UD

Vitamin B6

169.2

UD

UD

UD

UD

Vitamin B12

1355.4

UD

UD

UD

UD

Vitamin C

176.1

0.83 ± 0.07

0.69–0.98

100.5 ± 15.3

59.0 ± 9.2

Vitamin D2

397

UD

UD

UD

UD

Vitamin D3

384.6

UD

UD

UD

UD

Copper

63.6

0.009 ± 0.002

0.006–0.013

0.33 ± 0.05

0.20 ± 0.03

Iron

55.8

0.02 ± 0.01

0–0.04

0.07 ± 0.02

0.04 ± 0.09

Folate

441.4

0.51 ± 0.03

0.44–0.58

59.9 ± 11.7**

35.3 ± 6.9**

Selenium

79.0

0.036 ± 0.02

0–0.08

0.04 ± 0.01

0.04 ± 0.02

Zinc

65.4

0.10 ± 0.07

0–0.24

0.67 ± 0.20

0.64 ± 0.32

  1. *µmol/day **µg/day
  2. SC sieving coefficient, SE standard error, CI confidence interval, UD undetected
  3. aSC was calculated as \(\frac{{\left[ {C_{{{\text{eff}}}} } \right]}}{{\left[ {C_{{{\text{pl}}}} } \right]}}\), where Ceff is effluent concentration and Cpl is plasma concentration
  4. bDaily loss (mg) was calculated by Cpl × SC × effluent volume per 24 h
  5. cStandardized daily loss (mg) was estimated for CRRT dose 25 mL/kg/h for 24 h